Paxillin (phospho Tyr118) Polyclonal Antibody

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商品货号： PLP000216

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： PXN
蛋白名称： Paxillin
Human_gene_id： 5829
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5829
Human_swiss_prot_no： P49023
Human_swiss_link： http://www.uniprot.org/uniprotkb/P49023/entry
Mouse_gene_id： 19303
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19303
Mouse_swiss_prot_no： Q8VI36
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8VI36
Rat_gene_id： 360820
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360820
Rat_swiss_prot_no： Q66H76
Rat_swiss_link： http://www.uniprot.org/uniprot/Q66H76
特异性： Phospho-Paxillin (Y118) Polyclonal Antibody detects endogenous levels of Paxillin protein only when phosphorylated at Y118.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PXN; Paxillin
实测条带： 64kD
信号通路： Chemokine;VEGF;Focal adhesion;Leukocyte transendothelial migration;Regulates Actin and Cytoskeleton;
功能： function:Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).,PTM:Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.,similarity:Belongs to the paxillin family.,similarity:Contains 3 LIM zinc-binding domains.,similarity:Contains 4 LIM zinc-binding domains.,subunit:Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.,
相关产品： YT3608,YT3607,YT3606,YT3605,YT3604,YP0453,YP0444,YP0221,YP0220,YP0219,KA4221C,KA1636C,KA1635C
细胞定位： Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Cytoplasm, cell cortex . Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). .
组织表达： Brain,Epithelium,Lung,Placenta,T-cell,Uterus,
科研货号： PLP000216

Paxillin (phospho Tyr118) Polyclonal Antibody

Catalog No PLP000216

Product information

基因名称： PXN
蛋白名称： Paxillin
Human_gene_id： 5829
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5829
Human_swiss_prot_no： P49023
Human_swiss_link： http://www.uniprot.org/uniprotkb/P49023/entry
Mouse_gene_id： 19303
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19303
Mouse_swiss_prot_no： Q8VI36
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8VI36
Rat_gene_id： 360820
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360820
Rat_swiss_prot_no： Q66H76
Rat_swiss_link： http://www.uniprot.org/uniprot/Q66H76
特异性： Phospho-Paxillin (Y118) Polyclonal Antibody detects endogenous levels of Paxillin protein only when phosphorylated at Y118.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PXN; Paxillin
实测条带： 64kD
信号通路： Chemokine;VEGF;Focal adhesion;Leukocyte transendothelial migration;Regulates Actin and Cytoskeleton;
功能： function:Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).,PTM:Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.,similarity:Belongs to the paxillin family.,similarity:Contains 3 LIM zinc-binding domains.,similarity:Contains 4 LIM zinc-binding domains.,subunit:Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.,
相关产品： YT3608,YT3607,YT3606,YT3605,YT3604,YP0453,YP0444,YP0221,YP0220,YP0219,KA4221C,KA1636C,KA1635C
细胞定位： Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Cytoplasm, cell cortex . Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). .
组织表达： Brain,Epithelium,Lung,Placenta,T-cell,Uterus,
科研货号： PLP000216

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