mTOR (phospho Ser2448) Polyclonal Antibody

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商品货号： PLP000173

适应性： 人,小鼠,大鼠,牛,猪

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MTOR
蛋白名称： Serine/threonine-protein kinase mTOR
Human_gene_id： 2475
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2475
Human_swiss_prot_no： P42345
Human_swiss_link： http://www.uniprot.org/uniprotkb/P42345/entry
Mouse_gene_id： 56717
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56717
Mouse_swiss_prot_no： Q9JLN9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9JLN9
Rat_gene_id： 56718
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56718
Rat_swiss_prot_no： P42346
Rat_swiss_link： http://www.uniprot.org/uniprot/P42346
特异性： Phospho-mTOR (S2448) Polyclonal Antibody detects endogenous levels of mTOR protein only when phosphorylated at S2448.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar
实测条带： 289kD
信号通路： Regulates Angiogenesis; Insulin Receptor; ErbB/HER; mTOR; B Cell Receptor; PI3K/Akt; AMPK
功能： function:Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 FAT domain.,similarity:Contains 1 FATC domain.,similarity:Contains 1 PI3K/PI4K domain.,similarity:Contains 7 HEAT repeats.,subunit:Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.,tissue specificity:Expressed in numerous tissues, with highest levels in testis.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Cytoplasm . Nucleus, PML body . Microsome membrane . Lysosome membrane . Cytoplasmic vesicle, phagosome . Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113). .
组织表达： Expressed in numerous tissues, with highest levels in testis.
tag： hot
科研货号： PLP000173

mTOR (phospho Ser2448) Polyclonal Antibody

Catalog No PLP000173

Product information

基因名称： MTOR
蛋白名称： Serine/threonine-protein kinase mTOR
Human_gene_id： 2475
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2475
Human_swiss_prot_no： P42345
Human_swiss_link： http://www.uniprot.org/uniprotkb/P42345/entry
Mouse_gene_id： 56717
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56717
Mouse_swiss_prot_no： Q9JLN9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9JLN9
Rat_gene_id： 56718
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56718
Rat_swiss_prot_no： P42346
Rat_swiss_link： http://www.uniprot.org/uniprot/P42346
特异性： Phospho-mTOR (S2448) Polyclonal Antibody detects endogenous levels of mTOR protein only when phosphorylated at S2448.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar
实测条带： 289kD
信号通路： Regulates Angiogenesis; Insulin Receptor; ErbB/HER; mTOR; B Cell Receptor; PI3K/Akt; AMPK
功能： function:Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 FAT domain.,similarity:Contains 1 FATC domain.,similarity:Contains 1 PI3K/PI4K domain.,similarity:Contains 7 HEAT repeats.,subunit:Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.,tissue specificity:Expressed in numerous tissues, with highest levels in testis.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Cytoplasm . Nucleus, PML body . Microsome membrane . Lysosome membrane . Cytoplasmic vesicle, phagosome . Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113). .
组织表达： Expressed in numerous tissues, with highest levels in testis.
tag： hot
科研货号： PLP000173

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