ATF-2 (phospho Ser112) Polyclonal Antibody

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商品货号： PLP000022

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： ATF2
蛋白名称： Cyclic AMP-dependent transcription factor ATF-2
Human_gene_id： 1386
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1386
Human_swiss_prot_no： P15336
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15336/entry
Mouse_gene_id： 1.00048e+008
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100047997
Mouse_swiss_prot_no： P16951
Mouse_swiss_link： http://www.uniprot.org/uniprot/P16951
Rat_gene_id： 81647
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81647
Rat_swiss_prot_no： Q00969
Rat_swiss_link： http://www.uniprot.org/uniprot/Q00969
特异性： Phospho-ATF-2 (S112) Polyclonal Antibody detects endogenous levels of ATF-2 protein only when phosphorylated at S112.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro
分子量： 52kD
信号通路： B Cell Receptor; Stem cell pathway; MAPK_ERK_Growth;MAPK_G_Protein; PI3K/Akt; Protein_Acetylation
功能： caution:It is uncertain whether Met-1 or Met-19 is the initiator.,function:Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.,PTM:Phosphorylation of Thr-69 and Thr-71 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.,tissue specificity:Abundant expression seen in the brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
组织表达： Ubiquitously expressed, with more abundant expression in the brain.
tag： hot
科研货号： PLP000022

ATF-2 (phospho Ser112) Polyclonal Antibody

Catalog No PLP000022

Product information

基因名称： ATF2
蛋白名称： Cyclic AMP-dependent transcription factor ATF-2
Human_gene_id： 1386
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1386
Human_swiss_prot_no： P15336
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15336/entry
Mouse_gene_id： 1.00048e+008
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100047997
Mouse_swiss_prot_no： P16951
Mouse_swiss_link： http://www.uniprot.org/uniprot/P16951
Rat_gene_id： 81647
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81647
Rat_swiss_prot_no： Q00969
Rat_swiss_link： http://www.uniprot.org/uniprot/Q00969
特异性： Phospho-ATF-2 (S112) Polyclonal Antibody detects endogenous levels of ATF-2 protein only when phosphorylated at S112.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro
分子量： 52kD
信号通路： B Cell Receptor; Stem cell pathway; MAPK_ERK_Growth;MAPK_G_Protein; PI3K/Akt; Protein_Acetylation
功能： caution:It is uncertain whether Met-1 or Met-19 is the initiator.,function:Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.,PTM:Phosphorylation of Thr-69 and Thr-71 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.,tissue specificity:Abundant expression seen in the brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
组织表达： Ubiquitously expressed, with more abundant expression in the brain.
tag： hot
科研货号： PLP000022

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