AMPKα1 (phospho Ser496) Polyclonal Antibody

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商品货号： PLP000009

适应性： 人,小鼠,大鼠,犬,鱼

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： PRKAA1
蛋白名称： 5'-AMP-activated protein kinase catalytic subunit alpha-1
Human_gene_id： 5562
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5562
Human_swiss_prot_no： Q13131
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13131/entry
Mouse_gene_id： 105787
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=105787
Mouse_swiss_prot_no： Q5EG47
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q5EG47
Rat_gene_id： 65248
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65248
Rat_swiss_prot_no： P54645
Rat_swiss_link： http://www.uniprot.org/uniprot/P54645
特异性： Phospho-AMPKα1 (S496) Polyclonal Antibody detects endogenous levels of AMPKα1 protein only when phosphorylated at S496.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1
实测条带： 62kD
信号通路： Insulin Receptor; mTOR; AMPK
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.,function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Interacts with FNIP1 and FNIP2.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .
组织表达： Brain,Intestine,Liver,Mammary gland,Platelet,Testis
科研货号： PLP000009

AMPKα1 (phospho Ser496) Polyclonal Antibody

Catalog No PLP000009

Product information

基因名称： PRKAA1
蛋白名称： 5'-AMP-activated protein kinase catalytic subunit alpha-1
Human_gene_id： 5562
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5562
Human_swiss_prot_no： Q13131
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13131/entry
Mouse_gene_id： 105787
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=105787
Mouse_swiss_prot_no： Q5EG47
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q5EG47
Rat_gene_id： 65248
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65248
Rat_swiss_prot_no： P54645
Rat_swiss_link： http://www.uniprot.org/uniprot/P54645
特异性： Phospho-AMPKα1 (S496) Polyclonal Antibody detects endogenous levels of AMPKα1 protein only when phosphorylated at S496.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1
实测条带： 62kD
信号通路： Insulin Receptor; mTOR; AMPK
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.,function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Interacts with FNIP1 and FNIP2.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .
组织表达： Brain,Intestine,Liver,Mammary gland,Platelet,Testis
科研货号： PLP000009

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