Akt2 (phospho Ser474) Polyclonal Antibody

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商品货号： PLP000008

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： AKT2
蛋白名称： RAC-beta serine/threonine-protein kinase
Human_gene_id： 208
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=208
Human_swiss_prot_no： P31751
Human_swiss_link： http://www.uniprot.org/uniprotkb/P31751/entry
Mouse_gene_id： 11652
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11652
Mouse_swiss_prot_no： Q60823
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q60823
Rat_gene_id： 25233
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25233
Rat_swiss_prot_no： P47197
Rat_swiss_link： http://www.uniprot.org/uniprot/P47197
特异性： Phospho-Akt2 (S474) Polyclonal Antibody detects endogenous levels of Akt2 protein only when phosphorylated at S474.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： AKT2; RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta
实测条带： 56kD
信号通路： Regulation_Microtubule; Stem cell pathway; T_Cell_Receptor; Regulates Angiogenesis; Insulin Receptor; Toll_Like; ErbB/HER; AMPK; MAPK_ERK_Growth;MAPK_G_Protein; B_Cell_Antigen; Adherens_Junction; PI3K/Akt; mTOR
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.,function:General protein kinase capable of phosphorylating several known proteins.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B.,tissue specificity:In all human cell types so far analyzed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome . Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (By similarity). .
组织表达： Expressed in all cell types so far analyzed.
科研货号： PLP000008

Akt2 (phospho Ser474) Polyclonal Antibody

Catalog No PLP000008

Product information

基因名称： AKT2
蛋白名称： RAC-beta serine/threonine-protein kinase
Human_gene_id： 208
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=208
Human_swiss_prot_no： P31751
Human_swiss_link： http://www.uniprot.org/uniprotkb/P31751/entry
Mouse_gene_id： 11652
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11652
Mouse_swiss_prot_no： Q60823
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q60823
Rat_gene_id： 25233
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25233
Rat_swiss_prot_no： P47197
Rat_swiss_link： http://www.uniprot.org/uniprot/P47197
特异性： Phospho-Akt2 (S474) Polyclonal Antibody detects endogenous levels of Akt2 protein only when phosphorylated at S474.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： AKT2; RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta
实测条带： 56kD
信号通路： Regulation_Microtubule; Stem cell pathway; T_Cell_Receptor; Regulates Angiogenesis; Insulin Receptor; Toll_Like; ErbB/HER; AMPK; MAPK_ERK_Growth;MAPK_G_Protein; B_Cell_Antigen; Adherens_Junction; PI3K/Akt; mTOR
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.,function:General protein kinase capable of phosphorylating several known proteins.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B.,tissue specificity:In all human cell types so far analyzed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome . Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (By similarity). .
组织表达： Expressed in all cell types so far analyzed.
科研货号： PLP000008

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