Histone H4 (Acetyl Lys16) Polyclonal Antibody

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商品货号： PLN000185

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： HIST1H4A
蛋白名称： Histone H4
Human_gene_id： 121504
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=121504
Human_swiss_prot_no： P62805
Human_swiss_link： http://www.uniprot.org/uniprotkb/P62805/entry
Mouse_gene_id： 100041230
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100041230
Mouse_swiss_prot_no： P62806
Mouse_swiss_link： http://www.uniprot.org/uniprot/P62806
Rat_gene_id： 100360950
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100360950
Rat_swiss_prot_no： P62804
Rat_swiss_link： http://www.uniprot.org/uniprot/P62804
特异性： The antibody detects endogenous Histone H3 (Acetyl Lys16) protein.
组成： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:1000-2000 IHC 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： HIST1H4A; H4/A; H4FA; HIST1H4B; H4/I; H4FI; HIST1H4C; H4/G; H4FG; HIST1H4D; H4/B; H4FB; HIST1H4E; H4/J; H4FJ; HIST1H4F; H4/C; H4FC; HIST1H4H; H4/H; H4FH; HIST1H4I; H4/M; H4FM; HIST1H4J; H4/E; H4FE; HIST1H4K; H4/D; H4FD; HIST1H4L; H4/K; H4FK; HIST2H4A; H4/N; H4F2; H4FN; HIST2H4; HIST2H4B; H4/O; H4FO; HIST4H4; Histone H4;H4k16AC
实测条带： 14kD
信号通路： Systemic lupus erythematosus;
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Acetylation at Lys-6, Lys-9, Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.,PTM:Citrullination at Arg-4 by PADI4 impairs methylation.,PTM:Monomethylated, dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.,PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.,PTM:Sumoylated, which is associated with transcriptional repression.,PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.,similarity:Belongs to the histone H4 family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Chromosome.
组织表达： B-cell lymphoma,Bone marrow,Brain,Clones donated by HIP,Corpus call
科研货号： PLN000185

Histone H4 (Acetyl Lys16) Polyclonal Antibody

Catalog No PLN000185

Product information

基因名称： HIST1H4A
蛋白名称： Histone H4
Human_gene_id： 121504
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=121504
Human_swiss_prot_no： P62805
Human_swiss_link： http://www.uniprot.org/uniprotkb/P62805/entry
Mouse_gene_id： 100041230
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100041230
Mouse_swiss_prot_no： P62806
Mouse_swiss_link： http://www.uniprot.org/uniprot/P62806
Rat_gene_id： 100360950
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100360950
Rat_swiss_prot_no： P62804
Rat_swiss_link： http://www.uniprot.org/uniprot/P62804
特异性： The antibody detects endogenous Histone H3 (Acetyl Lys16) protein.
组成： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:1000-2000 IHC 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： HIST1H4A; H4/A; H4FA; HIST1H4B; H4/I; H4FI; HIST1H4C; H4/G; H4FG; HIST1H4D; H4/B; H4FB; HIST1H4E; H4/J; H4FJ; HIST1H4F; H4/C; H4FC; HIST1H4H; H4/H; H4FH; HIST1H4I; H4/M; H4FM; HIST1H4J; H4/E; H4FE; HIST1H4K; H4/D; H4FD; HIST1H4L; H4/K; H4FK; HIST2H4A; H4/N; H4F2; H4FN; HIST2H4; HIST2H4B; H4/O; H4FO; HIST4H4; Histone H4;H4k16AC
实测条带： 14kD
信号通路： Systemic lupus erythematosus;
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Acetylation at Lys-6, Lys-9, Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.,PTM:Citrullination at Arg-4 by PADI4 impairs methylation.,PTM:Monomethylated, dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.,PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.,PTM:Sumoylated, which is associated with transcriptional repression.,PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.,similarity:Belongs to the histone H4 family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Chromosome.
组织表达： B-cell lymphoma,Bone marrow,Brain,Clones donated by HIP,Corpus call
科研货号： PLN000185

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