Karyopherin α2 (Acetyl Lys22) rabbit pAb

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商品货号： PLN000153

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： KPNA2 RCH1 SRP1
蛋白名称： Karyopherin α2 (Acetyl Lys22)
Human_gene_id： 3838
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3838
Human_swiss_prot_no： P52292
Human_swiss_link： https://www.uniprot.org/uniprotkb/P52292/entry
Mouse_gene_id： 16647
Mouse_gene_link： https://www.uniprot.org/uniprot/16647
Mouse_swiss_prot_no： P52293
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P52293
特异性： This antibody detects endogenous levels of Human,Mouse,Rat Karyopherin α2 (Acetyl Lys22)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Importin subunit alpha-2 (Karyopherin subunit alpha-2;RAG cohort protein 1;SRP1-alpha)
实测条带： 60kD
功能： domain:Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.,domain:The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins.,domain:The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding.,function:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.,mass spectrometry: PubMed:11840567,similarity:Belongs to the importin alpha family.,similarity:Contains 1 IBB domain.,similarity:Contains 10 ARM repeats.,subunit:Forms a complex with importin subunit beta-1. Found in a complex with CSE1L/XPO2, Ran and KPNA2. Interacts with CSE1L/XPO2 and NBN. Interacts with ANP32E (By similarity). Interacts with HIV-1 Vpr and PLAG1.,tissue specificity:Expressed ubiquitously.,
相关产品： RS0001,RS0002,YM3028,YM3193
细胞定位： Cytoplasm . Nucleus .; Endoplasmic reticulum membrane. Golgi apparatus membrane . (Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein. .
组织表达： Expressed ubiquitously.
科研货号： PLN000153

Karyopherin α2 (Acetyl Lys22) rabbit pAb

Catalog No PLN000153

Product information

基因名称： KPNA2 RCH1 SRP1
蛋白名称： Karyopherin α2 (Acetyl Lys22)
Human_gene_id： 3838
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3838
Human_swiss_prot_no： P52292
Human_swiss_link： https://www.uniprot.org/uniprotkb/P52292/entry
Mouse_gene_id： 16647
Mouse_gene_link： https://www.uniprot.org/uniprot/16647
Mouse_swiss_prot_no： P52293
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P52293
特异性： This antibody detects endogenous levels of Human,Mouse,Rat Karyopherin α2 (Acetyl Lys22)
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Importin subunit alpha-2 (Karyopherin subunit alpha-2;RAG cohort protein 1;SRP1-alpha)
实测条带： 60kD
功能： domain:Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.,domain:The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins.,domain:The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding.,function:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.,mass spectrometry: PubMed:11840567,similarity:Belongs to the importin alpha family.,similarity:Contains 1 IBB domain.,similarity:Contains 10 ARM repeats.,subunit:Forms a complex with importin subunit beta-1. Found in a complex with CSE1L/XPO2, Ran and KPNA2. Interacts with CSE1L/XPO2 and NBN. Interacts with ANP32E (By similarity). Interacts with HIV-1 Vpr and PLAG1.,tissue specificity:Expressed ubiquitously.,
相关产品： RS0001,RS0002,YM3028,YM3193
细胞定位： Cytoplasm . Nucleus .; Endoplasmic reticulum membrane. Golgi apparatus membrane . (Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein. .
组织表达： Expressed ubiquitously.
科研货号： PLN000153

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