HMG-1 (Acetyl Lys12) Polyclonal Antibody

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商品货号： PLN000060

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： HMGB1
蛋白名称： High mobility group protein B1
Human_gene_id： 3146
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3146
Human_swiss_prot_no： P09429
Human_swiss_link： http://www.uniprot.org/uniprotkb/P09429/entry
Mouse_gene_id： 100862258
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100862258
Mouse_swiss_prot_no： P63158
Mouse_swiss_link： http://www.uniprot.org/uniprot/P63158
Rat_gene_id： 25459
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25459
Rat_swiss_prot_no： P63159
Rat_swiss_link： http://www.uniprot.org/uniprot/P63159
特异性： Acetyl-HMG-1 (K12) Polyclonal Antibody detects endogenous levels of HMG-1 protein only when acetylation at K12.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1
实测条带： about 30kd
信号通路： Base excision repair;
功能： function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Chromosome . Cytoplasm . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Endosome . Endoplasmic reticulum-Golgi intermediate compartment . In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptotic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune and non-immune cells such as macrophages, monocytes, neutrophils, dendritic cells and natural killer cells in response to various stimuli such as LPS and cytokines involves a nonconventional secretory process via secretory lysosomes (PubMed:12231511, PubMed:14532127, PubMed:15944249). Secreted by plasma cells in response to LPS (By similarity). Found on the surface of activated platelets (PubMed:11154118). An increased chromatin association is observed when associated with the adenovirus protein pVII (PubMed:27362237). .
组织表达： Ubiquitous. Expressed in platelets (PubMed:11154118).
tag： hot
科研货号： PLN000060

HMG-1 (Acetyl Lys12) Polyclonal Antibody

Catalog No PLN000060

Product information

基因名称： HMGB1
蛋白名称： High mobility group protein B1
Human_gene_id： 3146
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3146
Human_swiss_prot_no： P09429
Human_swiss_link： http://www.uniprot.org/uniprotkb/P09429/entry
Mouse_gene_id： 100862258
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100862258
Mouse_swiss_prot_no： P63158
Mouse_swiss_link： http://www.uniprot.org/uniprot/P63158
Rat_gene_id： 25459
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25459
Rat_swiss_prot_no： P63159
Rat_swiss_link： http://www.uniprot.org/uniprot/P63159
特异性： Acetyl-HMG-1 (K12) Polyclonal Antibody detects endogenous levels of HMG-1 protein only when acetylation at K12.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1
实测条带： about 30kd
信号通路： Base excision repair;
功能： function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Chromosome . Cytoplasm . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Endosome . Endoplasmic reticulum-Golgi intermediate compartment . In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptotic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune and non-immune cells such as macrophages, monocytes, neutrophils, dendritic cells and natural killer cells in response to various stimuli such as LPS and cytokines involves a nonconventional secretory process via secretory lysosomes (PubMed:12231511, PubMed:14532127, PubMed:15944249). Secreted by plasma cells in response to LPS (By similarity). Found on the surface of activated platelets (PubMed:11154118). An increased chromatin association is observed when associated with the adenovirus protein pVII (PubMed:27362237). .
组织表达： Ubiquitous. Expressed in platelets (PubMed:11154118).
tag： hot
科研货号： PLN000060

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