Myosin Heavy Chain, Smooth Muscle (SMMHC) (ABT206) Mouse mAb

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商品货号： PLD000224

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MYH11 KIAA0866
蛋白名称： Myosin Heavy Chain, Smooth Muscle
Human_gene_id： 4629
Human_gene_link： https://www.ncbi.nlm.nih.gov/gene/?term=MYH11
Human_swiss_prot_no： P35749
Human_swiss_link： https://www.uniprot.org/uniprotkb/P35749/entry
特异性： The antibody can specifically recognize human Myoglobin protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Mouse, Monoclonal/IgG1, Kappa
稀释： IHC-p 1:200-400
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： YM6894.pdf
Msds： MSDS_Antibody.pdf
其他名称： Myosin-11 (Myosin heavy chain 11;Myosin heavy chain, smooth muscle isoform;SMMHC)
功能： disease:A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.,disease:Defects in MYH11 are the cause of aortic aneurysm familial thoracic type 4 (AAT4) [MIM:132900]; also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content.,domain:The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.,function:Muscle contraction.,miscellaneous:Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).,similarity:Contains 1 IQ domain.,similarity:Contains 1 myosin head-like domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.,subunit:Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).,tissue specificity:Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
组织表达： Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.
tag： hot
科研货号： PLD000224

Myosin Heavy Chain, Smooth Muscle (SMMHC) (ABT206) Mouse mAb

Catalog No PLD000224

Product information

基因名称： MYH11 KIAA0866
蛋白名称： Myosin Heavy Chain, Smooth Muscle
Human_gene_id： 4629
Human_gene_link： https://www.ncbi.nlm.nih.gov/gene/?term=MYH11
Human_swiss_prot_no： P35749
Human_swiss_link： https://www.uniprot.org/uniprotkb/P35749/entry
特异性： The antibody can specifically recognize human Myoglobin protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Mouse, Monoclonal/IgG1, Kappa
稀释： IHC-p 1:200-400
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： YM6894.pdf
Msds： MSDS_Antibody.pdf
其他名称： Myosin-11 (Myosin heavy chain 11;Myosin heavy chain, smooth muscle isoform;SMMHC)
功能： disease:A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.,disease:Defects in MYH11 are the cause of aortic aneurysm familial thoracic type 4 (AAT4) [MIM:132900]; also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content.,domain:The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.,function:Muscle contraction.,miscellaneous:Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).,similarity:Contains 1 IQ domain.,similarity:Contains 1 myosin head-like domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.,subunit:Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).,tissue specificity:Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
组织表达： Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.
tag： hot
科研货号： PLD000224

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