Wilms' Tumor 1(WT1) (ABT-WT1) mouse mAb

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商品货号： PLD000084

适应性： 人,小鼠,大鼠,猪

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： WT1
蛋白名称： Wilms tumor protein (WT33)
Human_gene_id： 7490
Human_swiss_prot_no： P19544
Human_swiss_link： https://www.uniprot.org/uniprotkb/P19544/entry
特异性： This antibody detects endogenous levels of human Wilms' Tumor 1(WT1). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Mouse, Monoclonal/IgG2b, Kappa
稀释： WB 500-2000, IHC-p 1:200-400
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： YM6533.pdf
Msds： MSDS_Antibody.pdf
功能： disease:A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with EWSR1.,disease:Defects in WT1 are a cause of hypospadias. Hypospadias is a common malformation in which the urethra opens on the ventral side of the penis. It is considered a complex disorder with both genetic and environmental factors involved in the pathogenesis. Hypospadias can occur alone on an apparently multifactorial basis or as part of syndromes.,disease:Defects in WT1 are a cause of Meacham syndrome [MIM:608978]. Meacham syndrome is a rare sporadically occurring multiple malformation syndrome characterized by male pseudohermaphroditism with abnormal internal female genitalia comprising a uterus and double or septate vagina, complex congenital heart defect and diaphragmatic abnormalities.,disease:Defects in WT1 are a cause of Wilms tumor--aniridia--genitourinary anomalies--mental retardation syndrome (WAGR syndrome) [MIM:194072].,disease:Defects in WT1 are the cause of Denys-Drash syndrome (DDS) [MIM:194080]. DDS is a typical nephropathy characterized by diffuse mesangial sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier syndrome. Inheritance is autosomal dominant, but most cases are sporadic.,disease:Defects in WT1 are the cause of Frasier syndrome (FS) [MIM:136680]. FS is characterized by a slowly progressing nephropathy leading to renal failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with Denys-Drash syndrome. Inheritance is autosomal dominant.,disease:Defects in WT1 are the cause of isolated diffuse mesangial sclerosis (IDMS) [MIM:256370]. IDMS is an early-onset nephrotic syndrome occurring in the absence of other abnormalities and resulting in renal failure. Inheritance is autosomal recessive.,disease:Defects in WT1 are the cause of Wilms tumor 1 (WT1) [MIM:194070]. WT is an embryonal malignancy of the kidney that affects approximately 1 in 10'000 infants and young children. It occurs both in sporadic and hereditary forms.,function:Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'.,similarity:Belongs to the EGR C2H2-type zinc-finger protein family.,similarity:Contains 4 C2H2-type zinc fingers.,subunit:Interacts with WTIP (By similarity). Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY.,tissue specificity:Expressed in the kidney and a subset of hematopoietic cells.,
相关产品： YM6533R,YN2274,YM6533,YM6140,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus, nucleolus. Cytoplasm . Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm. .; [Isoform 1]: Nucleus speckle .; [Isoform 4]: Nucleus, nucleoplasm .
组织表达： Expressed in the kidney and a subset of hematopoietic cells.
tag： hot
科研货号： PLD000084

Wilms' Tumor 1(WT1) (ABT-WT1) mouse mAb

Catalog No PLD000084

Product information

基因名称： WT1
蛋白名称： Wilms tumor protein (WT33)
Human_gene_id： 7490
Human_swiss_prot_no： P19544
Human_swiss_link： https://www.uniprot.org/uniprotkb/P19544/entry
特异性： This antibody detects endogenous levels of human Wilms' Tumor 1(WT1). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Mouse, Monoclonal/IgG2b, Kappa
稀释： WB 500-2000, IHC-p 1:200-400
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： YM6533.pdf
Msds： MSDS_Antibody.pdf
功能： disease:A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with EWSR1.,disease:Defects in WT1 are a cause of hypospadias. Hypospadias is a common malformation in which the urethra opens on the ventral side of the penis. It is considered a complex disorder with both genetic and environmental factors involved in the pathogenesis. Hypospadias can occur alone on an apparently multifactorial basis or as part of syndromes.,disease:Defects in WT1 are a cause of Meacham syndrome [MIM:608978]. Meacham syndrome is a rare sporadically occurring multiple malformation syndrome characterized by male pseudohermaphroditism with abnormal internal female genitalia comprising a uterus and double or septate vagina, complex congenital heart defect and diaphragmatic abnormalities.,disease:Defects in WT1 are a cause of Wilms tumor--aniridia--genitourinary anomalies--mental retardation syndrome (WAGR syndrome) [MIM:194072].,disease:Defects in WT1 are the cause of Denys-Drash syndrome (DDS) [MIM:194080]. DDS is a typical nephropathy characterized by diffuse mesangial sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier syndrome. Inheritance is autosomal dominant, but most cases are sporadic.,disease:Defects in WT1 are the cause of Frasier syndrome (FS) [MIM:136680]. FS is characterized by a slowly progressing nephropathy leading to renal failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with Denys-Drash syndrome. Inheritance is autosomal dominant.,disease:Defects in WT1 are the cause of isolated diffuse mesangial sclerosis (IDMS) [MIM:256370]. IDMS is an early-onset nephrotic syndrome occurring in the absence of other abnormalities and resulting in renal failure. Inheritance is autosomal recessive.,disease:Defects in WT1 are the cause of Wilms tumor 1 (WT1) [MIM:194070]. WT is an embryonal malignancy of the kidney that affects approximately 1 in 10'000 infants and young children. It occurs both in sporadic and hereditary forms.,function:Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'.,similarity:Belongs to the EGR C2H2-type zinc-finger protein family.,similarity:Contains 4 C2H2-type zinc fingers.,subunit:Interacts with WTIP (By similarity). Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY.,tissue specificity:Expressed in the kidney and a subset of hematopoietic cells.,
相关产品： YM6533R,YN2274,YM6533,YM6140,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus, nucleolus. Cytoplasm . Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm. .; [Isoform 1]: Nucleus speckle .; [Isoform 4]: Nucleus, nucleoplasm .
组织表达： Expressed in the kidney and a subset of hematopoietic cells.
tag： hot
科研货号： PLD000084

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