功能： catalytic activity:NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).,developmental stage:Widely expressed in fetal tissues.,enzyme regulation:The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.,function:Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.,induction:By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.,pathway:Hormone biosynthesis; thyroid hormone biosynthesis.,PTM:N-glycosylated.,sequence caution:Translated as Arg.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,similarity:Contains 3 EF-hand domains.,similarity:In the N-terminal section; belongs to the peroxidase family.,subcellular location:Localizes to the apical membrane of epithelial cells.,subunit:Interacts with TXNDC11, TPO and CYBA.,tissue specificity:Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells.
组织表达： Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
功能： catalytic activity:NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).,developmental stage:Widely expressed in fetal tissues.,enzyme regulation:The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.,function:Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.,induction:By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.,pathway:Hormone biosynthesis; thyroid hormone biosynthesis.,PTM:N-glycosylated.,sequence caution:Translated as Arg.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,similarity:Contains 3 EF-hand domains.,similarity:In the N-terminal section; belongs to the peroxidase family.,subcellular location:Localizes to the apical membrane of epithelial cells.,subunit:Interacts with TXNDC11, TPO and CYBA.,tissue specificity:Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells.
组织表达： Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
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