功能： catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,function:May participate in both nuclear and mitochondrial post-replicative base excision repair (BER). In the nucleus functions in the PCNA-dependent BER pathway.,similarity:Belongs to the DNA repair enzymes AP/exoA family.,subcellular location:Colocalized partly with PCNA in nuclear foci.,subunit:Interacts with PCNA. This interaction is increased by misincorporation of uracil in nuclear DNA.,tissue specificity:Highly expressed in cells, adult brain and kidney. Weakly expressed in the fetal brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm. Mitochondrion . Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
组织表达： Highly expressed in brain and kidney. Weakly expressed in the fetal brain.
功能： catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,function:May participate in both nuclear and mitochondrial post-replicative base excision repair (BER). In the nucleus functions in the PCNA-dependent BER pathway.,similarity:Belongs to the DNA repair enzymes AP/exoA family.,subcellular location:Colocalized partly with PCNA in nuclear foci.,subunit:Interacts with PCNA. This interaction is increased by misincorporation of uracil in nuclear DNA.,tissue specificity:Highly expressed in cells, adult brain and kidney. Weakly expressed in the fetal brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm. Mitochondrion . Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
组织表达： Highly expressed in brain and kidney. Weakly expressed in the fetal brain.
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