功能: catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Inhibited by both FK506 and rapamycin.,function:May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the FKBP-type PPIase family.,similarity:Belongs to the FKBP-type PPIase family. FKBP1 subfamily.,similarity:Contains 1 PPIase FKBP-type domain.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm, cytosol . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能: catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Inhibited by both FK506 and rapamycin.,function:May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the FKBP-type PPIase family.,similarity:Belongs to the FKBP-type PPIase family. FKBP1 subfamily.,similarity:Contains 1 PPIase FKBP-type domain.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm, cytosol . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .