PI 3 kinase p85α Polyclonal Antibody

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商品货号： PLA019676

适应性： 人,小鼠,大鼠,猪

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： PIK3R1
蛋白名称： Phosphatidylinositol 3-kinase regulatory subunit alpha
Human_gene_id： 5295
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5295
Human_swiss_prot_no： P27986
Human_swiss_link： http://www.uniprot.org/uniprotkb/P27986/entry
Mouse_gene_id： 18708
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18708
Mouse_swiss_prot_no： P26450
Mouse_swiss_link： http://www.uniprot.org/uniprot/P26450
Rat_gene_id： 25513
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25513
Rat_swiss_prot_no： Q63787
Rat_swiss_link： http://www.uniprot.org/uniprot/Q63787
特异性： This antibody detects endogenous levels of PI 3-kinase p85α.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha
实测条带： 54+83kD
信号通路： Regulates Angiogenesis; Regulation_Microtubule; Regulation of Actin Dynamics; SAPK_JNK; Stem cell pathway; Insulin Receptor; ErbB/HER; AMPK; mTOR; B Cell Receptor; Adherens_Junction
功能： disease:Defects in PIK3R1 are a cause of severe insulin resistance.,domain:The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.,function:Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.,PTM:Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits. Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation. Interacts with SOCS7. Interacts with RUFY3 (By similarity). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C-terminus of both proteins and leads to increased production of HIV. Interacts with HCV NS5A. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1 and phosphorylated IRS4, as well as with NISCH and HCST.,tissue specificity:Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).,
相关产品： YT6156,YT3712,YT3711,YP0765,YM3680,YM3504,YM3503,YM3415,YM3409,YM3408,YD0080
细胞定位： nucleus,cytoplasm,cis-Golgi network,cytosol,plasma membrane,cell-cell junction,phosphatidylinositol 3-kinase complex,phosphatidylinositol 3-kinase complex, class IA,membrane,perinuclear endoplasmic reticulum membrane,
组织表达： Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
tag： hot
科研货号： PLA019676

PI 3 kinase p85α Polyclonal Antibody

Catalog No PLA019676

Product information

基因名称： PIK3R1
蛋白名称： Phosphatidylinositol 3-kinase regulatory subunit alpha
Human_gene_id： 5295
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5295
Human_swiss_prot_no： P27986
Human_swiss_link： http://www.uniprot.org/uniprotkb/P27986/entry
Mouse_gene_id： 18708
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18708
Mouse_swiss_prot_no： P26450
Mouse_swiss_link： http://www.uniprot.org/uniprot/P26450
Rat_gene_id： 25513
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25513
Rat_swiss_prot_no： Q63787
Rat_swiss_link： http://www.uniprot.org/uniprot/Q63787
特异性： This antibody detects endogenous levels of PI 3-kinase p85α.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha
实测条带： 54+83kD
信号通路： Regulates Angiogenesis; Regulation_Microtubule; Regulation of Actin Dynamics; SAPK_JNK; Stem cell pathway; Insulin Receptor; ErbB/HER; AMPK; mTOR; B Cell Receptor; Adherens_Junction
功能： disease:Defects in PIK3R1 are a cause of severe insulin resistance.,domain:The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.,function:Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.,PTM:Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits. Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation. Interacts with SOCS7. Interacts with RUFY3 (By similarity). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C-terminus of both proteins and leads to increased production of HIV. Interacts with HCV NS5A. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1 and phosphorylated IRS4, as well as with NISCH and HCST.,tissue specificity:Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).,
相关产品： YT6156,YT3712,YT3711,YP0765,YM3680,YM3504,YM3503,YM3415,YM3409,YM3408,YD0080
细胞定位： nucleus,cytoplasm,cis-Golgi network,cytosol,plasma membrane,cell-cell junction,phosphatidylinositol 3-kinase complex,phosphatidylinositol 3-kinase complex, class IA,membrane,perinuclear endoplasmic reticulum membrane,
组织表达： Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
tag： hot
科研货号： PLA019676

Hunan UPT Biotechnology Co.,Ltd

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