信号通路： Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;
功能： disease:Defects in C8A are a cause of complement C8 deficiency type I [MIM:120950]. Patients with deficiency of C8 suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,function:C8 is a constituent of the membrane attack complex. C8 binds to the C5b-7 complex, forming the C5b-8 complex. C5-b8 binds C9 and acts as a catalyst in the polymerization of C9.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 TSP type-1 domains.,subunit:C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted. Cell membrane; Multi-pass membrane protein. Secreted as soluble protein. Inserts into the cell membrane of target cells.
信号通路： Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;
功能： disease:Defects in C8A are a cause of complement C8 deficiency type I [MIM:120950]. Patients with deficiency of C8 suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,function:C8 is a constituent of the membrane attack complex. C8 binds to the C5b-7 complex, forming the C5b-8 complex. C5-b8 binds C9 and acts as a catalyst in the polymerization of C9.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 TSP type-1 domains.,subunit:C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted. Cell membrane; Multi-pass membrane protein. Secreted as soluble protein. Inserts into the cell membrane of target cells.
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