功能: caution:Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.,function:Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.,online information:Haptoglobin entry,online information:The Singapore human mutation and polymorphism database,polymorphism:In the human populations there are two major allelic forms, alpha-1 with 83 residues and alpha-2 with 142 residues. These alleles determine the 3 major phenotypes HP*1F/HP*1S and HP*2FS. The two main alleles of HP*1 are called HP*1F (fast) and HP*1S (slow).,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Tetramer of two alpha and two beta chains.,tissue specificity:Expressed by the liver and secreted in plasma.,tissue specificity:In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in hepatoma G2 and leukemia molt-4 cell lines.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Secreted.
组织表达: Expressed by the liver and secreted in plasma.
功能: caution:Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.,function:Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.,online information:Haptoglobin entry,online information:The Singapore human mutation and polymorphism database,polymorphism:In the human populations there are two major allelic forms, alpha-1 with 83 residues and alpha-2 with 142 residues. These alleles determine the 3 major phenotypes HP*1F/HP*1S and HP*2FS. The two main alleles of HP*1 are called HP*1F (fast) and HP*1S (slow).,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Tetramer of two alpha and two beta chains.,tissue specificity:Expressed by the liver and secreted in plasma.,tissue specificity:In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in hepatoma G2 and leukemia molt-4 cell lines.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Secreted.
组织表达: Expressed by the liver and secreted in plasma.