其他名称： Disheveled-associated activator of morphogenesis 1
实测条带： 123kD
信号通路： WNT;WNT-T CELL
功能： domain:The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.,function:Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.,similarity:Belongs to the formin homology family.,similarity:Contains 1 DAD (diaphanous autoregulatory) domain.,similarity:Contains 1 FH1 (formin homology 1) domain.,similarity:Contains 1 FH2 (formin homology 2) domain.,similarity:Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.,subcellular location:Perinuclear.,subunit:Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA.,tissue specificity:Expressed in all tissues examined.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Perinuclear.
组织表达： Expressed in all tissues examined.
科研货号： PLA019477
DAAM1 Polyclonal Antibody
Catalog NoPLA019477
Product information
基因名称： DAAM1 KIAA0666
蛋白名称： Disheveled-associated activator of morphogenesis 1
其他名称： Disheveled-associated activator of morphogenesis 1
实测条带： 123kD
信号通路： WNT;WNT-T CELL
功能： domain:The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.,function:Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.,similarity:Belongs to the formin homology family.,similarity:Contains 1 DAD (diaphanous autoregulatory) domain.,similarity:Contains 1 FH1 (formin homology 1) domain.,similarity:Contains 1 FH2 (formin homology 2) domain.,similarity:Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.,subcellular location:Perinuclear.,subunit:Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA.,tissue specificity:Expressed in all tissues examined.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Perinuclear.
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