其他名称： C-type lectin domain family 4 member M (CD209 antigen-like protein 1;DC-SIGN-related protein;DC-SIGNR;Dendritic cell-specific ICAM-3-grabbing non-integrin 2;DC-SIGN2;Liver/lymph node-specific ICAM-3-grabbing non-integrin;L-SIGN;CD antigen CD299)
实测条带： 60kD
功能： alternative products:Additional isoforms seem to exist. Several splicing events may occur independently in a modular way. Deletion of the transmembrane domain encoding exon through alternative splicing produces soluble isoforms,domain:The tandem repeat domain, also called neck domain, mediates oligermerization.,function:Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.,miscellaneous:In vitro, is a receptor for HIV-1 and transmits HIV-1 to permissive T-cells.,online information:DC-SIGNR,polymorphism:The number of repeats in the tandem repeat domain is shown to vary between 3 and 9 per allele thus contributing to a further variability in addition to alternative splicing. The shown 7 repeats-containing form has been shown to be the most frequent one (53.9%) in a study with 350 Caucasian individuals.,similarity:Contains 1 C-type lectin domain.,subunit:Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus S protein.,tissue specificity:Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 5]: Secreted .; [Isoform 6]: Secreted .; [Isoform 7]: Secreted .; [Isoform 10]: Secreted .
组织表达： Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.
科研货号： PLA019468
CD299 Polyclonal Antibody
Catalog NoPLA019468
Product information
基因名称： CLEC4M CD209L CD209L1 CD299
蛋白名称： C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)
其他名称： C-type lectin domain family 4 member M (CD209 antigen-like protein 1;DC-SIGN-related protein;DC-SIGNR;Dendritic cell-specific ICAM-3-grabbing non-integrin 2;DC-SIGN2;Liver/lymph node-specific ICAM-3-grabbing non-integrin;L-SIGN;CD antigen CD299)
实测条带： 60kD
功能： alternative products:Additional isoforms seem to exist. Several splicing events may occur independently in a modular way. Deletion of the transmembrane domain encoding exon through alternative splicing produces soluble isoforms,domain:The tandem repeat domain, also called neck domain, mediates oligermerization.,function:Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.,miscellaneous:In vitro, is a receptor for HIV-1 and transmits HIV-1 to permissive T-cells.,online information:DC-SIGNR,polymorphism:The number of repeats in the tandem repeat domain is shown to vary between 3 and 9 per allele thus contributing to a further variability in addition to alternative splicing. The shown 7 repeats-containing form has been shown to be the most frequent one (53.9%) in a study with 350 Caucasian individuals.,similarity:Contains 1 C-type lectin domain.,subunit:Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus S protein.,tissue specificity:Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 5]: Secreted .; [Isoform 6]: Secreted .; [Isoform 7]: Secreted .; [Isoform 10]: Secreted .
组织表达： Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.
在线咨询
湘公网安备