其他名称： WNT1-inducible-signaling pathway protein 3 (WISP-3) (CCN family member 6)
实测条带： 55kD
功能： disease:Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]. PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging.,function:Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,tissue specificity:Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted . Mitochondrion . Associated with membranes. .
组织表达： Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine (PubMed:9843955, PubMed:10471507). Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes (PubMed:10471507).
科研货号： PLA019430
WISP-3 Polyclonal Antibody
Catalog NoPLA019430
Product information
基因名称： WISP3 CCN6 UNQ462/PRO790/PRO956
蛋白名称： WNT1-inducible-signaling pathway protein 3 (WISP-3) (CCN family member 6)
其他名称： WNT1-inducible-signaling pathway protein 3 (WISP-3) (CCN family member 6)
实测条带： 55kD
功能： disease:Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]. PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging.,function:Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,tissue specificity:Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted . Mitochondrion . Associated with membranes. .
组织表达： Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine (PubMed:9843955, PubMed:10471507). Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes (PubMed:10471507).
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