Caspase-1 Polyclonal Antibody

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商品货号： PLA019357

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： CASP1 IL1BC IL1BCE
蛋白名称： Caspase1
Human_gene_id： 834
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=834
Human_swiss_prot_no： P29466
Human_swiss_link： http://www.uniprot.org/uniprotkb/P29466/entry
Mouse_gene_id： 12362
Mouse_swiss_prot_no： P29452
Mouse_swiss_link： http://www.uniprot.org/uniprot/P29452
Rat_swiss_prot_no： P43527
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P43527
特异性： Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
分子量： 45kD
实测条带： 45kD, 35kD, cleaced isform p10 :10kD
信号通路： NOD-like receptor;Cytosolic DNA-sensing pathway;Amyotrophic lateral sclerosis (ALS);
功能： alternative products:Additional isoforms seem to exist,catalytic activity:Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.,enzyme regulation:Specifically inhibited by the cowpox virus Crma protein.,function:Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18.,tissue specificity:Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell membrane .
组织表达： Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
tag： hot
科研货号： PLA019357

Caspase-1 Polyclonal Antibody

Catalog No PLA019357

Product information

基因名称： CASP1 IL1BC IL1BCE
蛋白名称： Caspase1
Human_gene_id： 834
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=834
Human_swiss_prot_no： P29466
Human_swiss_link： http://www.uniprot.org/uniprotkb/P29466/entry
Mouse_gene_id： 12362
Mouse_swiss_prot_no： P29452
Mouse_swiss_link： http://www.uniprot.org/uniprot/P29452
Rat_swiss_prot_no： P43527
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P43527
特异性： Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
分子量： 45kD
实测条带： 45kD, 35kD, cleaced isform p10 :10kD
信号通路： NOD-like receptor;Cytosolic DNA-sensing pathway;Amyotrophic lateral sclerosis (ALS);
功能： alternative products:Additional isoforms seem to exist,catalytic activity:Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.,enzyme regulation:Specifically inhibited by the cowpox virus Crma protein.,function:Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18.,tissue specificity:Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell membrane .
组织表达： Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
tag： hot
科研货号： PLA019357

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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