其他名称： Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1)
实测条带： 40kD
信号通路： Neuroactive ligand-receptor interaction;
功能： function:Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:The C-terminus interacts with SHANK1 PDZ domain.,tissue specificity:Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Multi-pass membrane protein. Cytoplasm. Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
组织表达： Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
其他名称： Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1)
实测条带： 40kD
信号通路： Neuroactive ligand-receptor interaction;
功能： function:Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:The C-terminus interacts with SHANK1 PDZ domain.,tissue specificity:Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Multi-pass membrane protein. Cytoplasm. Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
组织表达： Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
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