其他名称： EDA; ED1; EDA2; Ectodysplasin-A; Ectodermal dysplasia protein; EDA protein
实测条带： 42kD
信号通路： Cytokine-cytokine receptor interaction;
功能： alternative products:Additional isoforms seem to exist,disease:Defects in EDA are a cause of hypodontia [MIM:300606]. Hypodontia is agenesis of two or more permanent teeth without associated systemic disorders. Hypodontia due to EDA defects is an X-linked recessive disorder. Affected individuals have normal hair, skin, and nails, but lack primary and permanent teeth.,disease:Defects in EDA are the cause of ectodermal dysplasia, type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.,function:Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor XEDAR.,PTM:N-glycosylated.,PTM:Processing by furin produces a secreted form.,similarity:Belongs to the tumor necrosis factor family.,similarity:Contains 1 collagen-like domain.,subunit:Homotrimer. The homotrimers may then dimerize and form higher order oligomers.,tissue specificity:Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type II membrane protein .; [Ectodysplasin-A, secreted form]: Secreted .
组织表达： Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
其他名称： EDA; ED1; EDA2; Ectodysplasin-A; Ectodermal dysplasia protein; EDA protein
实测条带： 42kD
信号通路： Cytokine-cytokine receptor interaction;
功能： alternative products:Additional isoforms seem to exist,disease:Defects in EDA are a cause of hypodontia [MIM:300606]. Hypodontia is agenesis of two or more permanent teeth without associated systemic disorders. Hypodontia due to EDA defects is an X-linked recessive disorder. Affected individuals have normal hair, skin, and nails, but lack primary and permanent teeth.,disease:Defects in EDA are the cause of ectodermal dysplasia, type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.,function:Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor XEDAR.,PTM:N-glycosylated.,PTM:Processing by furin produces a secreted form.,similarity:Belongs to the tumor necrosis factor family.,similarity:Contains 1 collagen-like domain.,subunit:Homotrimer. The homotrimers may then dimerize and form higher order oligomers.,tissue specificity:Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type II membrane protein .; [Ectodysplasin-A, secreted form]: Secreted .
组织表达： Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
在线咨询
湘公网安备