SIRP-α1/β1 Polyclonal Antibody

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商品货号： PLA019255

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： SIRPA/SIRPB1
蛋白名称： Tyrosine-protein phosphatase non-receptor type substrate 1/Signal-regulatory protein beta-1 isoform 3
Human_gene_id： 140885/10326/100653194
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140885/10326/100653194
Human_swiss_prot_no： P78324/Q5TFQ8
Human_swiss_link： http://www.uniprot.org/uniprotkb/P78324/Q5TFQ8/entry
Mouse_gene_id： 19261
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19261
Rat_gene_id： 25528
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25528
Rat_swiss_prot_no： P97710
Rat_swiss_link： http://www.uniprot.org/uniprot/P97710
特异性： SIRP-α1/β1 Polyclonal Antibody detects endogenous levels of SIRP-α1/β1 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD172a; SIRPB1; Signal-regulatory protein beta-1 isoform 3; SIRP-beta-1 isoform 3
实测条带： 55kD
功能： function:Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.,PTM:N-glycosylated.,PTM:Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C1-type (immunoglobulin-like) domains.,subunit:Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.,tissue specificity:Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Single-pass type I membrane protein.
组织表达： Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
科研货号： PLA019255

SIRP-α1/β1 Polyclonal Antibody

Catalog No PLA019255

Product information

基因名称： SIRPA/SIRPB1
蛋白名称： Tyrosine-protein phosphatase non-receptor type substrate 1/Signal-regulatory protein beta-1 isoform 3
Human_gene_id： 140885/10326/100653194
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140885/10326/100653194
Human_swiss_prot_no： P78324/Q5TFQ8
Human_swiss_link： http://www.uniprot.org/uniprotkb/P78324/Q5TFQ8/entry
Mouse_gene_id： 19261
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19261
Rat_gene_id： 25528
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25528
Rat_swiss_prot_no： P97710
Rat_swiss_link： http://www.uniprot.org/uniprot/P97710
特异性： SIRP-α1/β1 Polyclonal Antibody detects endogenous levels of SIRP-α1/β1 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD172a; SIRPB1; Signal-regulatory protein beta-1 isoform 3; SIRP-beta-1 isoform 3
实测条带： 55kD
功能： function:Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.,PTM:N-glycosylated.,PTM:Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C1-type (immunoglobulin-like) domains.,subunit:Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.,tissue specificity:Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Single-pass type I membrane protein.
组织表达： Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
科研货号： PLA019255

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