Histone H2A Polyclonal Antibody

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商品货号： PLA019157

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： HIST1H2AG/HIST1H2AI/HIST1H2AK/HIST1H2AL/HIST1H2AM
蛋白名称： Histone H2A type 1
Human_gene_id： 8329/8330/8332/8336/8969
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8329
Human_swiss_prot_no： P0C0S8
Human_swiss_link： http://www.uniprot.org/uniprotkb/P0C0S8/entry
Mouse_gene_id： 319164
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=319164
Mouse_swiss_prot_no： P22752
Mouse_swiss_link： http://www.uniprot.org/uniprot/P22752
Rat_swiss_prot_no： P02262
Rat_swiss_link： http://www.uniprot.org/uniprot/P02262
特异性： Histone H2A Polyclonal Antibody detects endogenous levels of Histone H2A protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p
实测条带： 15kD
信号通路： Systemic lupus erythematosus;
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.,PTM:Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.,PTM:Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.,PTM:The chromatin-associated form is phosphorylated on Thr-121 during mitosis.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Chromosome.
组织表达： Bone,Brain,Colon,Eye,Lymph,PCR rescued clones,Placenta,Sple
科研货号： PLA019157

Histone H2A Polyclonal Antibody

Catalog No PLA019157

Product information

基因名称： HIST1H2AG/HIST1H2AI/HIST1H2AK/HIST1H2AL/HIST1H2AM
蛋白名称： Histone H2A type 1
Human_gene_id： 8329/8330/8332/8336/8969
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8329
Human_swiss_prot_no： P0C0S8
Human_swiss_link： http://www.uniprot.org/uniprotkb/P0C0S8/entry
Mouse_gene_id： 319164
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=319164
Mouse_swiss_prot_no： P22752
Mouse_swiss_link： http://www.uniprot.org/uniprot/P22752
Rat_swiss_prot_no： P02262
Rat_swiss_link： http://www.uniprot.org/uniprot/P02262
特异性： Histone H2A Polyclonal Antibody detects endogenous levels of Histone H2A protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p
实测条带： 15kD
信号通路： Systemic lupus erythematosus;
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.,PTM:Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.,PTM:Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.,PTM:The chromatin-associated form is phosphorylated on Thr-121 during mitosis.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Chromosome.
组织表达： Bone,Brain,Colon,Eye,Lymph,PCR rescued clones,Placenta,Sple
科研货号： PLA019157

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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