Neuropilin Polyclonal Antibody

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商品货号： PLA019118

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： NRP1
蛋白名称： Neuropilin-1
Human_gene_id： 8829
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8829
Human_swiss_prot_no： O14786
Human_swiss_link： http://www.uniprot.org/uniprotkb/O14786/entry
Mouse_gene_id： 18186
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18186
Mouse_swiss_prot_no： P97333
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97333
Rat_gene_id： 246331
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246331
Rat_swiss_prot_no： Q9QWJ9
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9QWJ9
特异性： Neuropilin Polyclonal Antibody detects endogenous levels of Neuropilin protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： NRP1; NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD304
实测条带： 100kD
信号通路： Axon guidance;
功能： function:The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.,function:The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.,similarity:Belongs to the neuropilin family.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 1 MAM domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 F5/8 type C domains.,subunit:Heterodimer with NRP2 (Probable). Binds PLXNB1.,tissue specificity:The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 2]: Secreted .; Mitochondrion membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein . Cytoplasm .
组织表达： [Isoform 1]: The expression of isoforms 1 and 2 does not seem to overlap. Expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain (PubMed:10688880, PubMed:9529250). Expressed in olfactory epithelium (at protein level) (PubMed:33082293). Expressed in the central nervous system, including olfactory related regions such as the olfactory tubercles and paraolfactory gyri (PubMed:33082293). ; [Isoform 2]: The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules.
科研货号： PLA019118

Neuropilin Polyclonal Antibody

Catalog No PLA019118

Product information

基因名称： NRP1
蛋白名称： Neuropilin-1
Human_gene_id： 8829
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8829
Human_swiss_prot_no： O14786
Human_swiss_link： http://www.uniprot.org/uniprotkb/O14786/entry
Mouse_gene_id： 18186
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18186
Mouse_swiss_prot_no： P97333
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97333
Rat_gene_id： 246331
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246331
Rat_swiss_prot_no： Q9QWJ9
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9QWJ9
特异性： Neuropilin Polyclonal Antibody detects endogenous levels of Neuropilin protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： NRP1; NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD304
实测条带： 100kD
信号通路： Axon guidance;
功能： function:The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.,function:The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.,similarity:Belongs to the neuropilin family.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 1 MAM domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 F5/8 type C domains.,subunit:Heterodimer with NRP2 (Probable). Binds PLXNB1.,tissue specificity:The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 2]: Secreted .; Mitochondrion membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein . Cytoplasm .
组织表达： [Isoform 1]: The expression of isoforms 1 and 2 does not seem to overlap. Expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain (PubMed:10688880, PubMed:9529250). Expressed in olfactory epithelium (at protein level) (PubMed:33082293). Expressed in the central nervous system, including olfactory related regions such as the olfactory tubercles and paraolfactory gyri (PubMed:33082293). ; [Isoform 2]: The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules.
科研货号： PLA019118

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