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EKLF Polyclonal Antibody
商品货号: PLA019097
适 应 性: 人,大鼠,小鼠,
WB ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: KLF1
  • 蛋白名称: Krueppel-like factor 1
  • Human_gene_id: 10661
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10661
  • Human_swiss_prot_no: Q13351
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q13351/entry
  • Mouse_swiss_prot_no: P46099
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P46099
  • 特异性: EKLF Polyclonal Antibody detects endogenous levels of EKLF protein only when acetylation at K274.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: KLF1; EKLF; Krueppel-like factor 1; Erythroid krueppel-like transcription factor; EKLF
  • 实测条带: 38kD
  • 功能: function:Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. When sumoylation, acts as a Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor, by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.,PTM:Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity.,PTM:Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity.,PTM:Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subcellular location:Colocalizes with SUMO1 in nuclear speckles.,subunit:Interacts with CBP and EP300; the interactions enhance the transactivation activity. Interacts with PCAF; the interaction does not acetylate EKLF and inhibits its transactivation activity.,tissue specificity:Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Nucleus . Colocalizes with SUMO1 in nuclear speckles. .
  • 组织表达: Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
  • tag: hot
  • 科研货号: PLA019097
EKLF Polyclonal Antibody
Catalog No PLA019097
Product information
  • 基因名称: KLF1
  • 蛋白名称: Krueppel-like factor 1
  • Human_gene_id: 10661
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10661
  • Human_swiss_prot_no: Q13351
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q13351/entry
  • Mouse_swiss_prot_no: P46099
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P46099
  • 特异性: EKLF Polyclonal Antibody detects endogenous levels of EKLF protein only when acetylation at K274.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: KLF1; EKLF; Krueppel-like factor 1; Erythroid krueppel-like transcription factor; EKLF
  • 实测条带: 38kD
  • 功能: function:Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. When sumoylation, acts as a Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor, by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.,PTM:Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity.,PTM:Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity.,PTM:Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subcellular location:Colocalizes with SUMO1 in nuclear speckles.,subunit:Interacts with CBP and EP300; the interactions enhance the transactivation activity. Interacts with PCAF; the interaction does not acetylate EKLF and inhibits its transactivation activity.,tissue specificity:Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Nucleus . Colocalizes with SUMO1 in nuclear speckles. .
  • 组织表达: Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
  • tag: hot
  • 科研货号: PLA019097
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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