其他名称： RFC1; RFC140; Replication factor C subunit 1; Activator 1 140 kDa subunit; A1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; DNA-binding protein PO-GAReplication factor C 140 kDa subunit; RF-C 140 kDa subunit; RFC140; Replication factor C large subunit
实测条带： 130kD
信号通路： DNA replication;Nucleotide excision repair;Mismatch repair;
功能： function:Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.,function:The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the activator 1 large subunit family.,similarity:Contains 1 BRCT domain.,subunit:Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA.,tissue specificity:Wide tissue distribution. Undetectable in placental tissue.,
相关产品： YT5385,YT5314,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus.
组织表达： Wide tissue distribution. Undetectable in placental tissue.
其他名称： RFC1; RFC140; Replication factor C subunit 1; Activator 1 140 kDa subunit; A1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; DNA-binding protein PO-GAReplication factor C 140 kDa subunit; RF-C 140 kDa subunit; RFC140; Replication factor C large subunit
实测条带： 130kD
信号通路： DNA replication;Nucleotide excision repair;Mismatch repair;
功能： function:Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.,function:The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the activator 1 large subunit family.,similarity:Contains 1 BRCT domain.,subunit:Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA.,tissue specificity:Wide tissue distribution. Undetectable in placental tissue.,
相关产品： YT5385,YT5314,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus.
组织表达： Wide tissue distribution. Undetectable in placental tissue.
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