CD71/TfR Polyclonal Antibody

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商品货号： PLA019054

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： TFRC
蛋白名称： Transferrin receptor protein 1
Human_gene_id： 7037
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7037
Human_swiss_prot_no： P02786
Human_swiss_link： http://www.uniprot.org/uniprotkb/P02786/entry
Mouse_swiss_prot_no： Q62351
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q62351
特异性： CD71 Polyclonal Antibody detects endogenous levels of CD71 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： TFRC; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71
实测条带： 85kD
信号通路： Endocytosis;Hematopoietic cell lineage;
功能： function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.,miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.,PTM:N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.,PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.,PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).,similarity:Belongs to the peptidase M28 family. M28B subfamily.,similarity:Contains 1 PA (protease associated) domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1, serum form]: Secreted .
组织表达： Brain,Epithelium,Erythroleukemia,Eye,Human endometrium carcinoma cell line,Liver,Pl
科研货号： PLA019054

CD71/TfR Polyclonal Antibody

Catalog No PLA019054

Product information

基因名称： TFRC
蛋白名称： Transferrin receptor protein 1
Human_gene_id： 7037
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7037
Human_swiss_prot_no： P02786
Human_swiss_link： http://www.uniprot.org/uniprotkb/P02786/entry
Mouse_swiss_prot_no： Q62351
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q62351
特异性： CD71 Polyclonal Antibody detects endogenous levels of CD71 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： TFRC; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71
实测条带： 85kD
信号通路： Endocytosis;Hematopoietic cell lineage;
功能： function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.,miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.,PTM:N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.,PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.,PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).,similarity:Belongs to the peptidase M28 family. M28B subfamily.,similarity:Contains 1 PA (protease associated) domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1, serum form]: Secreted .
组织表达： Brain,Epithelium,Erythroleukemia,Eye,Human endometrium carcinoma cell line,Liver,Pl
科研货号： PLA019054

Hunan UPT Biotechnology Co.,Ltd

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