信号通路： Glycolysis / Gluconeogenesis;Ascorbate and aldarate metabolism;Fatty acid metabolism;Valine; leucine and isoleucine degradation;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Limonene and pinene degradation;
功能： catalytic activity:An aldehyde + NAD(+) + H(2)O = an acid + NADH.,disease:Defects in ALDH2 are a cause of acute alcohol sensitivity [MIM:610251]. There are wide individual differences in responses to drinking alcohol. Recent estimates claim that subjective effects (how people feel when they drink) vary from 200%-300% in the adult population, and ethanol metabolism (how quickly alcohol is absorbed into the bloodstream and metabolized by the liver) varies by approximately 200%. Unfortunately, alcohol researchers know very little about why such drastic differences occur between individuals and how individual differences in alcohol sensitivity might link drinking behavior with problematic alcohol-related outcomes.,pathway:Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.,polymorphism:Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication in Orientals and South American Indians, as compared to Caucasians.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer.,
信号通路： Glycolysis / Gluconeogenesis;Ascorbate and aldarate metabolism;Fatty acid metabolism;Valine; leucine and isoleucine degradation;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Limonene and pinene degradation;
功能： catalytic activity:An aldehyde + NAD(+) + H(2)O = an acid + NADH.,disease:Defects in ALDH2 are a cause of acute alcohol sensitivity [MIM:610251]. There are wide individual differences in responses to drinking alcohol. Recent estimates claim that subjective effects (how people feel when they drink) vary from 200%-300% in the adult population, and ethanol metabolism (how quickly alcohol is absorbed into the bloodstream and metabolized by the liver) varies by approximately 200%. Unfortunately, alcohol researchers know very little about why such drastic differences occur between individuals and how individual differences in alcohol sensitivity might link drinking behavior with problematic alcohol-related outcomes.,pathway:Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.,polymorphism:Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication in Orientals and South American Indians, as compared to Caucasians.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer.,
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