Amphiphysin II Polyclonal Antibody

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商品货号： PLA019014

适应性： 小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： BIN1
蛋白名称： Myc box-dependent-interacting protein 1
Human_gene_id： 274
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=274
Human_swiss_prot_no： O00499
Human_swiss_link： http://www.uniprot.org/uniprotkb/O00499/entry
Mouse_gene_id： 30948
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30948
Mouse_swiss_prot_no： O08539
Mouse_swiss_link： http://www.uniprot.org/uniprot/O08539
Rat_gene_id： 117028
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117028
Rat_swiss_prot_no： O08839
Rat_swiss_link： http://www.uniprot.org/uniprot/O08839
特异性： Amphiphysin II Polyclonal Antibody detects endogenous levels of Amphiphysin II protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： BIN1; AMPHL; Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1
实测条带： 64kD
功能： alternative products:Additional isoforms seem to exist,disease:Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.,function:May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.,PTM:Phosphorylated by protein kinase C.,similarity:Contains 1 BAR domain.,similarity:Contains 1 SH3 domain.,subunit:Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Binds to SYNJ1 and DNM1 through its SH3 domain, and to clathrin through a region outside of the SH3 domain. Also binds AP2A2. Interacts with the N-terminal transactivation domain of MYC in a manner requiring the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2. Interacts with HCV NS5A through its SH3 domain.,tissue specificity:Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform BIN1]: Nucleus . Cytoplasm . Endosome . Cell membrane, sarcolemma, T-tubule .; [Isoform IIA]: Cytoplasm .
组织表达： Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667). Expressed in oligodendrocytes (PubMed:27488240). Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240). Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
科研货号： PLA019014

Amphiphysin II Polyclonal Antibody

Catalog No PLA019014

Product information

基因名称： BIN1
蛋白名称： Myc box-dependent-interacting protein 1
Human_gene_id： 274
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=274
Human_swiss_prot_no： O00499
Human_swiss_link： http://www.uniprot.org/uniprotkb/O00499/entry
Mouse_gene_id： 30948
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30948
Mouse_swiss_prot_no： O08539
Mouse_swiss_link： http://www.uniprot.org/uniprot/O08539
Rat_gene_id： 117028
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117028
Rat_swiss_prot_no： O08839
Rat_swiss_link： http://www.uniprot.org/uniprot/O08839
特异性： Amphiphysin II Polyclonal Antibody detects endogenous levels of Amphiphysin II protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： BIN1; AMPHL; Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1
实测条带： 64kD
功能： alternative products:Additional isoforms seem to exist,disease:Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.,function:May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.,PTM:Phosphorylated by protein kinase C.,similarity:Contains 1 BAR domain.,similarity:Contains 1 SH3 domain.,subunit:Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Binds to SYNJ1 and DNM1 through its SH3 domain, and to clathrin through a region outside of the SH3 domain. Also binds AP2A2. Interacts with the N-terminal transactivation domain of MYC in a manner requiring the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2. Interacts with HCV NS5A through its SH3 domain.,tissue specificity:Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform BIN1]: Nucleus . Cytoplasm . Endosome . Cell membrane, sarcolemma, T-tubule .; [Isoform IIA]: Cytoplasm .
组织表达： Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667). Expressed in oligodendrocytes (PubMed:27488240). Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240). Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
科研货号： PLA019014

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