其他名称： KLRB1; CLEC5B; NKRP1A; Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD161
实测条带： 25kD
功能： function:Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.,induction:By IL12 in NK cells.,online information:NKRP1,PTM:N-glycosylated. Contains sialic acid residues.,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.,tissue specificity:Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Single-pass type II membrane protein .
组织表达： Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
科研货号： PLA018979
CD161 Polyclonal Antibody
Catalog NoPLA018979
Product information
基因名称： KLRB1
蛋白名称： Killer cell lectin-like receptor subfamily B member 1
其他名称： KLRB1; CLEC5B; NKRP1A; Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD161
实测条带： 25kD
功能： function:Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.,induction:By IL12 in NK cells.,online information:NKRP1,PTM:N-glycosylated. Contains sialic acid residues.,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.,tissue specificity:Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Single-pass type II membrane protein .
组织表达： Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
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