功能： disease:Defects in CD79B are a cause of non-Bruton type agammaglobulinemia [MIM:601495]. Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells.,function:Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.,online information:CD79B mutation db,PTM:Phosphorylated on tyrosine upon B-cell activation.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subcellular location:Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.,subunit:Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.,tissue specificity:B-cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. .
组织表达： B-cells.
科研货号： PLA018961
CD79b Polyclonal Antibody
Catalog NoPLA018961
Product information
基因名称： CD79B
蛋白名称： B-cell antigen receptor complex-associated protein beta chain
功能： disease:Defects in CD79B are a cause of non-Bruton type agammaglobulinemia [MIM:601495]. Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells.,function:Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.,online information:CD79B mutation db,PTM:Phosphorylated on tyrosine upon B-cell activation.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subcellular location:Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.,subunit:Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.,tissue specificity:B-cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. .
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