信号通路： Pyrimidine metabolism;beta-Alanine metabolism;Pantothenate and CoA biosynthesis;Drug metabolism;
功能： catalytic activity:5,6-dihydrouracil + NADP(+) = uracil + NADPH.,cofactor:Binds 2 4Fe-4S clusters. Contains approximately 33 iron atoms per molecule.,cofactor:Binds 2 FAD.,cofactor:Binds 2 FMN.,disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.,function:Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.,pathway:Amino-acid biosynthesis; beta-alanine biosynthesis.,similarity:Belongs to the dihydropyrimidine dehydrogenase family.,similarity:Contains 3 4Fe-4S ferredoxin-type domains.,subunit:Homodimer.,tissue specificity:Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm.
组织表达： Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
信号通路： Pyrimidine metabolism;beta-Alanine metabolism;Pantothenate and CoA biosynthesis;Drug metabolism;
功能： catalytic activity:5,6-dihydrouracil + NADP(+) = uracil + NADPH.,cofactor:Binds 2 4Fe-4S clusters. Contains approximately 33 iron atoms per molecule.,cofactor:Binds 2 FAD.,cofactor:Binds 2 FMN.,disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.,function:Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.,pathway:Amino-acid biosynthesis; beta-alanine biosynthesis.,similarity:Belongs to the dihydropyrimidine dehydrogenase family.,similarity:Contains 3 4Fe-4S ferredoxin-type domains.,subunit:Homodimer.,tissue specificity:Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm.
组织表达： Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
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