Prothrombin Polyclonal Antibody

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商品货号： PLA018850

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： F2
蛋白名称： Prothrombin
Human_gene_id： 2147
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2147
Human_swiss_prot_no： P00734
Human_swiss_link： http://www.uniprot.org/uniprotkb/P00734/entry
Mouse_gene_id： 14061
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14061
Mouse_swiss_prot_no： P19221
Mouse_swiss_link： http://www.uniprot.org/uniprot/P19221
Rat_swiss_prot_no： P18292
Rat_swiss_link： http://www.uniprot.org/uniprot/P18292
特异性： Prothrombin Polyclonal Antibody detects endogenous levels of Prothrombin protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： F2; Prothrombin; Coagulation factor II
实测条带： 70kD
信号通路： Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Regulates Actin and Cytoskeleton;
功能： catalytic activity:Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.,disease:Defects in F2 are the cause of various forms of dysprothrombinemia [MIM:176930].,disease:Genetic variations in F2 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.,miscellaneous:It is not known whether 1 or 2 smaller activation peptides, with additional cleavage after Arg-314, are released in natural blood clotting.,miscellaneous:Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin.,miscellaneous:The cleavage after Arg-198, observed in vitro, does not occur in plasma.,miscellaneous:Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa.,online information:Thrombin entry,pharmaceutical:The peptide TP508 also known as Chrysalin (Orthologic) could be used to accelerate repair of both soft and hard tissues.,PTM:The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 kringle domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
相关产品： YT5126,YT3862,YC0077,KA3977C,KA3520C
细胞定位： Secreted, extracellular space.
组织表达： Expressed by the liver and secreted in plasma.
tag： hot
科研货号： PLA018850

Prothrombin Polyclonal Antibody

Catalog No PLA018850

Product information

基因名称： F2
蛋白名称： Prothrombin
Human_gene_id： 2147
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2147
Human_swiss_prot_no： P00734
Human_swiss_link： http://www.uniprot.org/uniprotkb/P00734/entry
Mouse_gene_id： 14061
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14061
Mouse_swiss_prot_no： P19221
Mouse_swiss_link： http://www.uniprot.org/uniprot/P19221
Rat_swiss_prot_no： P18292
Rat_swiss_link： http://www.uniprot.org/uniprot/P18292
特异性： Prothrombin Polyclonal Antibody detects endogenous levels of Prothrombin protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： F2; Prothrombin; Coagulation factor II
实测条带： 70kD
信号通路： Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Regulates Actin and Cytoskeleton;
功能： catalytic activity:Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.,disease:Defects in F2 are the cause of various forms of dysprothrombinemia [MIM:176930].,disease:Genetic variations in F2 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.,miscellaneous:It is not known whether 1 or 2 smaller activation peptides, with additional cleavage after Arg-314, are released in natural blood clotting.,miscellaneous:Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin.,miscellaneous:The cleavage after Arg-198, observed in vitro, does not occur in plasma.,miscellaneous:Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa.,online information:Thrombin entry,pharmaceutical:The peptide TP508 also known as Chrysalin (Orthologic) could be used to accelerate repair of both soft and hard tissues.,PTM:The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 kringle domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
相关产品： YT5126,YT3862,YC0077,KA3977C,KA3520C
细胞定位： Secreted, extracellular space.
组织表达： Expressed by the liver and secreted in plasma.
tag： hot
科研货号： PLA018850

Hunan UPT Biotechnology Co.,Ltd

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