其他名称： UBE4B; HDNB1; KIAA0684; UFD2; Ubiquitin conjugation factor E4 B; Homozygously deleted in neuroblastoma 1; Ubiquitin fusion degradation protein 2
分子量： 146kD
信号通路： Ubiquitin mediated proteolysis;
功能： function:Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.,PTM:Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.,similarity:Belongs to the ubiquitin conjugation factor E4 family.,similarity:Contains 1 U-box domain.,subunit:Interacts with VCP.,tissue specificity:Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus .
组织表达： Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788). Almost undetectable in lung and spleen (PubMed:11802788).
其他名称： UBE4B; HDNB1; KIAA0684; UFD2; Ubiquitin conjugation factor E4 B; Homozygously deleted in neuroblastoma 1; Ubiquitin fusion degradation protein 2
分子量： 146kD
信号通路： Ubiquitin mediated proteolysis;
功能： function:Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.,PTM:Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.,similarity:Belongs to the ubiquitin conjugation factor E4 family.,similarity:Contains 1 U-box domain.,subunit:Interacts with VCP.,tissue specificity:Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus .
组织表达： Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788). Almost undetectable in lung and spleen (PubMed:11802788).
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