T-type Ca++ CP α1H Polyclonal Antibody

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商品货号： PLA018527

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： CACNA1H
蛋白名称： Voltage-dependent T-type calcium channel subunit alpha-1H
Human_gene_id： 8912
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8912
Human_swiss_prot_no： O95180
Human_swiss_link： http://www.uniprot.org/uniprotkb/O95180/entry
Mouse_swiss_prot_no： O88427
Mouse_swiss_link： http://www.uniprot.org/uniprot/O88427
Rat_gene_id： 114862
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114862
Rat_swiss_prot_no： Q9EQ60
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9EQ60
特异性： T-type Ca++ CP α1H Polyclonal Antibody detects endogenous levels of T-type Ca++ CP α1H protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CACNA1H; Voltage-dependent T-type calcium channel subunit alpha-1H; Low-voltage-activated calcium channel alpha1 3.2 subunit; Voltage-gated calcium channel subunit alpha Cav3.2
实测条带： 259kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;Calcium;
功能： disease:Defects in CACNA1H are a cause of susceptibility to idiopathic generalized epilepsy type 6 (IGE6) [MIM:611942]. IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. IGE6 is a polygenic and multifactorial disease.,domain:Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.,function:Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.,PTM:In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.,similarity:Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.,tissue specificity:Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific.,
相关产品： YT4773,YM3537,RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Interaction with STAC increases expression at the cell membrane. .
组织表达： Expressed in the adrenal glomerulosa (at protein level) (PubMed:25907736, PubMed:27729216). In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen (PubMed:9670923, PubMed:9930755). In the heart, expressed in blood vessels. ; [Isoform 1]: Expressed in testis, primarily in the germ cells, but not in other portions of the reproductive tract, such as ductus deferens (PubMed:11751928). Expressed in the brain (PubMed:11751928). ; [Isoform 2]: Expressed in testis, primarily in the germ cells, but not in other portions of the reproductive tract, such as ductus deferens (PubMed:11751928). Not expressed in the brain (PubMed:11751928).
科研货号： PLA018527

T-type Ca++ CP α1H Polyclonal Antibody

Catalog No PLA018527

Product information

基因名称： CACNA1H
蛋白名称： Voltage-dependent T-type calcium channel subunit alpha-1H
Human_gene_id： 8912
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8912
Human_swiss_prot_no： O95180
Human_swiss_link： http://www.uniprot.org/uniprotkb/O95180/entry
Mouse_swiss_prot_no： O88427
Mouse_swiss_link： http://www.uniprot.org/uniprot/O88427
Rat_gene_id： 114862
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114862
Rat_swiss_prot_no： Q9EQ60
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9EQ60
特异性： T-type Ca++ CP α1H Polyclonal Antibody detects endogenous levels of T-type Ca++ CP α1H protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CACNA1H; Voltage-dependent T-type calcium channel subunit alpha-1H; Low-voltage-activated calcium channel alpha1 3.2 subunit; Voltage-gated calcium channel subunit alpha Cav3.2
实测条带： 259kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;Calcium;
功能： disease:Defects in CACNA1H are a cause of susceptibility to idiopathic generalized epilepsy type 6 (IGE6) [MIM:611942]. IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. IGE6 is a polygenic and multifactorial disease.,domain:Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.,function:Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.,PTM:In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.,similarity:Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.,tissue specificity:Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific.,
相关产品： YT4773,YM3537,RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Interaction with STAC increases expression at the cell membrane. .
组织表达： Expressed in the adrenal glomerulosa (at protein level) (PubMed:25907736, PubMed:27729216). In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen (PubMed:9670923, PubMed:9930755). In the heart, expressed in blood vessels. ; [Isoform 1]: Expressed in testis, primarily in the germ cells, but not in other portions of the reproductive tract, such as ductus deferens (PubMed:11751928). Expressed in the brain (PubMed:11751928). ; [Isoform 2]: Expressed in testis, primarily in the germ cells, but not in other portions of the reproductive tract, such as ductus deferens (PubMed:11751928). Not expressed in the brain (PubMed:11751928).
科研货号： PLA018527

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