Tsg 101 Polyclonal Antibody

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商品货号： PLA018514

适应性： 人,小鼠,大鼠,猴

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： TSG101
蛋白名称： Tumor susceptibility gene 101 protein
Human_gene_id： 7251
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7251
Human_swiss_prot_no： Q99816
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q99816/entry
Mouse_gene_id： 22088
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22088
Mouse_swiss_prot_no： Q61187
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61187
Rat_gene_id： 292925
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=292925
Rat_swiss_prot_no： Q6IRE4
Rat_swiss_link： http://www.uniprot.org/uniprot/Q6IRE4
特异性： Tsg 101 Polyclonal Antibody detects endogenous levels of Tsg 101 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： TSG101; Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
实测条带： 45kD
信号通路： Endocytosis;
功能： alternative products:Additional isoforms seem to exist. Several shorter isoforms are detected in primary breast cancers and other tumors,domain:The coiled coil domain may interact with stathmin.,domain:The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently.,domain:The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein.,function:Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.,PTM:Monoubiquitinated at multiple sites by LRSAM1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form.,similarity:Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.,similarity:Contains 1 SB (steadiness box) domain.,similarity:Contains 1 UEV (ubiquitin E2 variant) domain.,subcellular location:Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.,subunit:Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and a FAM125/MVB12 protein (FAM125A or -B) in a 1:1:1:1 stoechiometry. Interacts with VPS37A, VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36. Self-associates. Interacts with FAM125A/MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis but not for viral budding. Interacts with HIV-1 p6. Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola virus VP40. Interacts with EIAV p9; the interaction has been shown in vitro.,tissue specificity:Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.,
相关产品： YT4760,KA3876C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Late endosome membrane ; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody, Midbody ring . Nucleus . Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. .
组织表达： Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
科研货号： PLA018514

Tsg 101 Polyclonal Antibody

Catalog No PLA018514

Product information

基因名称： TSG101
蛋白名称： Tumor susceptibility gene 101 protein
Human_gene_id： 7251
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7251
Human_swiss_prot_no： Q99816
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q99816/entry
Mouse_gene_id： 22088
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22088
Mouse_swiss_prot_no： Q61187
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61187
Rat_gene_id： 292925
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=292925
Rat_swiss_prot_no： Q6IRE4
Rat_swiss_link： http://www.uniprot.org/uniprot/Q6IRE4
特异性： Tsg 101 Polyclonal Antibody detects endogenous levels of Tsg 101 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： TSG101; Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
实测条带： 45kD
信号通路： Endocytosis;
功能： alternative products:Additional isoforms seem to exist. Several shorter isoforms are detected in primary breast cancers and other tumors,domain:The coiled coil domain may interact with stathmin.,domain:The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently.,domain:The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein.,function:Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.,PTM:Monoubiquitinated at multiple sites by LRSAM1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form.,similarity:Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.,similarity:Contains 1 SB (steadiness box) domain.,similarity:Contains 1 UEV (ubiquitin E2 variant) domain.,subcellular location:Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.,subunit:Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and a FAM125/MVB12 protein (FAM125A or -B) in a 1:1:1:1 stoechiometry. Interacts with VPS37A, VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36. Self-associates. Interacts with FAM125A/MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis but not for viral budding. Interacts with HIV-1 p6. Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola virus VP40. Interacts with EIAV p9; the interaction has been shown in vitro.,tissue specificity:Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.,
相关产品： YT4760,KA3876C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Late endosome membrane ; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody, Midbody ring . Nucleus . Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. .
组织表达： Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
科研货号： PLA018514

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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