其他名称： TRAF4; CART1; MLN62; RNF83; TNF receptor-associated factor 4; Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83
实测条带： 53kD
信号通路： Pathways in cancer;Small cell lung cancer;
功能： domain:The coiled coil domain mediates homo- and hetero-oligomerization.,domain:The MATH/TRAF domain binds to receptor cytoplasmic domains.,function:Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Seems to mediate activation of NF-kappa-B and JNK and seems to be involved in apoptosis. May play a role in the development of respiratory tract.,similarity:Contains 1 MATH domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 TRAF-type zinc fingers.,subunit:Homotrimer (Probable). Associates with LTBR/TNFRSF3 and NGFR/TNFRSF16. Interacts with TGFB1I1.,tissue specificity:Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.,
组织表达： Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.
其他名称： TRAF4; CART1; MLN62; RNF83; TNF receptor-associated factor 4; Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83
实测条带： 53kD
信号通路： Pathways in cancer;Small cell lung cancer;
功能： domain:The coiled coil domain mediates homo- and hetero-oligomerization.,domain:The MATH/TRAF domain binds to receptor cytoplasmic domains.,function:Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Seems to mediate activation of NF-kappa-B and JNK and seems to be involved in apoptosis. May play a role in the development of respiratory tract.,similarity:Contains 1 MATH domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 TRAF-type zinc fingers.,subunit:Homotrimer (Probable). Associates with LTBR/TNFRSF3 and NGFR/TNFRSF16. Interacts with TGFB1I1.,tissue specificity:Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.,
组织表达： Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.
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