其他名称： BCCIP; TOK1; BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; Protein TOK-1
实测条带： 35kD
功能： developmental stage:Isoform 1 is expressed throughout the cell cycle while isoform 2 is expressed following mitosis and peaks in the G1/S phase of the cell cycle.,function:May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).,miscellaneous:HT1080 cells that constitutively express low levels of BCCIP display increased levels of spontaneous single-stranded DNA and double-strand breaks.,similarity:Belongs to the BCP1 family.,subcellular location:Colocalizes with BRCA2 in discrete nuclear foci.,subunit:Interacts with BRCA2, CDKN1A and MTDH/LYRIC.,tissue specificity:Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle pole . Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342). .; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Isoform 1/beta tends to be less abundant at, and less strongly associated with, centrosomes than isoform 2/alpha. .; [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Isoform 2/alpha tends to be more abundant at, and more strongly associated with, centrosomes than isoform 1/beta. .
组织表达： Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
其他名称： BCCIP; TOK1; BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; Protein TOK-1
实测条带： 35kD
功能： developmental stage:Isoform 1 is expressed throughout the cell cycle while isoform 2 is expressed following mitosis and peaks in the G1/S phase of the cell cycle.,function:May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).,miscellaneous:HT1080 cells that constitutively express low levels of BCCIP display increased levels of spontaneous single-stranded DNA and double-strand breaks.,similarity:Belongs to the BCP1 family.,subcellular location:Colocalizes with BRCA2 in discrete nuclear foci.,subunit:Interacts with BRCA2, CDKN1A and MTDH/LYRIC.,tissue specificity:Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle pole . Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342). .; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Isoform 1/beta tends to be less abundant at, and less strongly associated with, centrosomes than isoform 2/alpha. .; [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Isoform 2/alpha tends to be more abundant at, and more strongly associated with, centrosomes than isoform 1/beta. .
组织表达： Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
在线咨询
湘公网安备