信号通路： Cytokine-cytokine receptor interaction;Antigen processing and presentation;Type I diabetes mellitus;
功能： disease:Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae.,disease:Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis.,function:Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.,online information:Lymphotoxin entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the tumor necrosis factor family.,subcellular location:The homotrimer is secreted. The heterotrimer is membrane-associated.,subunit:Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
信号通路： Cytokine-cytokine receptor interaction;Antigen processing and presentation;Type I diabetes mellitus;
功能： disease:Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae.,disease:Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis.,function:Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.,online information:Lymphotoxin entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the tumor necrosis factor family.,subcellular location:The homotrimer is secreted. The heterotrimer is membrane-associated.,subunit:Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
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