功能： catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,disease:Defects in ALPL are a cause of hypophosphatasia adult type (hypophosphatasia) [MIM:146300].,disease:Defects in ALPL are a cause of hypophosphatasia childhood (hypophosphatasia) [MIM:241510].,disease:Defects in ALPL are a cause of hypophosphatasia infantile (hypophosphatasia) [MIM:241500]; an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto).,function:This isozyme may play a role in skeletal mineralization.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,online information:Tissue nonspecific alkaline phosphatase gene mutations database,PTM:Glycosylated.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,
相关产品： YT5563,YT4683,RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Lipid-anchor, GPI-anchor . Extracellular vesicle membrane ; Lipid-anchor, GPI-anchor . Mitochondrion membrane ; Lipid-anchor, GPI-anchor . Mitochondrion intermembrane space . Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. Localizes to the mitochondria of thermogenic fat cells: tethered to mitochondrial membranes via a GPI-anchor and probably resides in the mitochondrion intermembrane space. .
功能： catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,disease:Defects in ALPL are a cause of hypophosphatasia adult type (hypophosphatasia) [MIM:146300].,disease:Defects in ALPL are a cause of hypophosphatasia childhood (hypophosphatasia) [MIM:241510].,disease:Defects in ALPL are a cause of hypophosphatasia infantile (hypophosphatasia) [MIM:241500]; an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto).,function:This isozyme may play a role in skeletal mineralization.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,online information:Tissue nonspecific alkaline phosphatase gene mutations database,PTM:Glycosylated.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,
相关产品： YT5563,YT4683,RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Lipid-anchor, GPI-anchor . Extracellular vesicle membrane ; Lipid-anchor, GPI-anchor . Mitochondrion membrane ; Lipid-anchor, GPI-anchor . Mitochondrion intermembrane space . Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. Localizes to the mitochondria of thermogenic fat cells: tethered to mitochondrial membranes via a GPI-anchor and probably resides in the mitochondrion intermembrane space. .
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