Tyrosine Hydroxylase rabbit pAb

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商品货号： PLA018398

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： TH
蛋白名称： Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH),Tyrosine Hydrolase
Human_gene_id： 7054
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7054
Human_swiss_prot_no： P07101
Human_swiss_link： http://www.uniprot.org/uniprotkb/P07101/entry
Mouse_gene_id： 21823
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21823
Mouse_swiss_prot_no： P24529
Mouse_swiss_link： http://www.uniprot.org/uniprot/P24529
Rat_gene_id： 25085
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25085
Rat_swiss_prot_no： P04177
Rat_swiss_link： http://www.uniprot.org/uniprot/P04177
特异性： TH Polyclonal Antibody detects endogenous levels of TH protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： TH; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH
实测条带： 56kD
信号通路： Tyrosine metabolism;Parkinson's disease;
功能： catalytic activity:L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.,enzyme regulation:Phosphorylation leads to an increase in the catalytic activity.,function:Plays an important role in the physiology of adrenergic neurons.,online information:Tyrosine hydroxylase entry,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,tissue specificity:Mainly expressed in the brain and adrenal glands.,
相关产品： YT6106,YT4640,YT4638,YT4637,YP0863,YP0589,YP0588,KA1191C,KA1190C,KA1189C
细胞定位： Cytoplasm, perinuclear region . Nucleus . Cell projection, axon . Cytoplasm . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals. .
组织表达： Mainly expressed in the brain and adrenal glands.
tag： hot
科研货号： PLA018398

Tyrosine Hydroxylase rabbit pAb

Catalog No PLA018398

Product information

基因名称： TH
蛋白名称： Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH),Tyrosine Hydrolase
Human_gene_id： 7054
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7054
Human_swiss_prot_no： P07101
Human_swiss_link： http://www.uniprot.org/uniprotkb/P07101/entry
Mouse_gene_id： 21823
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21823
Mouse_swiss_prot_no： P24529
Mouse_swiss_link： http://www.uniprot.org/uniprot/P24529
Rat_gene_id： 25085
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25085
Rat_swiss_prot_no： P04177
Rat_swiss_link： http://www.uniprot.org/uniprot/P04177
特异性： TH Polyclonal Antibody detects endogenous levels of TH protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： TH; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH
实测条带： 56kD
信号通路： Tyrosine metabolism;Parkinson's disease;
功能： catalytic activity:L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.,enzyme regulation:Phosphorylation leads to an increase in the catalytic activity.,function:Plays an important role in the physiology of adrenergic neurons.,online information:Tyrosine hydroxylase entry,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,tissue specificity:Mainly expressed in the brain and adrenal glands.,
相关产品： YT6106,YT4640,YT4638,YT4637,YP0863,YP0589,YP0588,KA1191C,KA1190C,KA1189C
细胞定位： Cytoplasm, perinuclear region . Nucleus . Cell projection, axon . Cytoplasm . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals. .
组织表达： Mainly expressed in the brain and adrenal glands.
tag： hot
科研货号： PLA018398

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