其他名称： TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1
实测条带： 43kD
功能： disease:Defects in TGIF1 are the cause of holoprosencephaly type 4 (HPE4) [MIM:142946]. Holoprosencephaly (HPE) [MIM:236100] is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.,function:Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.,similarity:Belongs to the TALE/TGIF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with CTBP, SMAD2, SMAD3 and HDAC1.,
其他名称： TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1
实测条带： 43kD
功能： disease:Defects in TGIF1 are the cause of holoprosencephaly type 4 (HPE4) [MIM:142946]. Holoprosencephaly (HPE) [MIM:236100] is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.,function:Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.,similarity:Belongs to the TALE/TGIF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with CTBP, SMAD2, SMAD3 and HDAC1.,
在线咨询
湘公网安备