其他名称： TDG; G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase
实测条带： 46kD
信号通路： Base excision repair;
功能： function:In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.,PTM:Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA.,similarity:Belongs to the TDG/mug DNA glycosylase family.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Colon,Lung,Pooled,Thymus,
科研货号： PLA018360
TDG Polyclonal Antibody
Catalog NoPLA018360
Product information
基因名称： TDG
蛋白名称： G/T mismatch-specific thymine DNA glycosylase
其他名称： TDG; G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase
实测条带： 46kD
信号通路： Base excision repair;
功能： function:In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.,PTM:Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA.,similarity:Belongs to the TDG/mug DNA glycosylase family.,
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