其他名称： SOCS2; CIS2; SSI2; STATI2; Suppressor of cytokine signaling 2; SOCS-2; Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2
实测条带： 22kD
信号通路： Jak_STAT;Insulin_Receptor;Type II diabetes mellitus;
功能： domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,function:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,induction:By a subset of cytokines, including erythropoietin and granulocyte-macrophage colony stimulating factor (GM-CSF).,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SOCS box domain.,subunit:Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.,tissue specificity:High expression in heart, placenta, lung, kidney and prostate.,
相关产品： YT5877,YT4363,RS0001,RS0002,YM3028,YM3029
细胞定位： cytoplasm,cytosol,
组织表达： High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.
其他名称： SOCS2; CIS2; SSI2; STATI2; Suppressor of cytokine signaling 2; SOCS-2; Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2
实测条带： 22kD
信号通路： Jak_STAT;Insulin_Receptor;Type II diabetes mellitus;
功能： domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,function:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,induction:By a subset of cytokines, including erythropoietin and granulocyte-macrophage colony stimulating factor (GM-CSF).,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SOCS box domain.,subunit:Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.,tissue specificity:High expression in heart, placenta, lung, kidney and prostate.,
相关产品： YT5877,YT4363,RS0001,RS0002,YM3028,YM3029
细胞定位： cytoplasm,cytosol,
组织表达： High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.
在线咨询
湘公网安备