Smad6 Polyclonal Antibody

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商品货号： PLA018150

适应性： 人,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： SMAD6
蛋白名称： Mothers against decapentaplegic homolog 6
Human_gene_id： 4091
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4091
Human_swiss_prot_no： O43541
Human_swiss_link： http://www.uniprot.org/uniprotkb/O43541/entry
Mouse_gene_id： 17130
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17130
Mouse_swiss_prot_no： O35182
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35182
特异性： Smad6 Polyclonal Antibody detects endogenous levels of Smad6 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SMAD6; MADH6; Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6
实测条带： 62kD
信号通路： TGF-beta;
功能： function:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.,PTM:Phosphorylated by BMP type 1 receptor kinase and by PRKX.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subunit:Interacts with NEDD4L (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX.,tissue specificity:Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.,
相关产品： YT4338,YM0585,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
科研货号： PLA018150

Smad6 Polyclonal Antibody

Catalog No PLA018150

Product information

基因名称： SMAD6
蛋白名称： Mothers against decapentaplegic homolog 6
Human_gene_id： 4091
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4091
Human_swiss_prot_no： O43541
Human_swiss_link： http://www.uniprot.org/uniprotkb/O43541/entry
Mouse_gene_id： 17130
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17130
Mouse_swiss_prot_no： O35182
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35182
特异性： Smad6 Polyclonal Antibody detects endogenous levels of Smad6 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SMAD6; MADH6; Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6
实测条带： 62kD
信号通路： TGF-beta;
功能： function:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.,PTM:Phosphorylated by BMP type 1 receptor kinase and by PRKX.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subunit:Interacts with NEDD4L (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX.,tissue specificity:Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.,
相关产品： YT4338,YM0585,RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
科研货号： PLA018150

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