Smad1/5/9 Polyclonal Antibody

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商品货号： PLA018145

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： SMAD1/SMAD5/SMAD9
蛋白名称： Mothers against decapentaplegic homolog 1/Mothers against decapentaplegic homolog 5/Mothers against decapentaplegic homolog 9
Human_gene_id： 4086/4090/4093
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4086
Human_swiss_prot_no： Q15797/Q99717/O15198
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15797/entry
Mouse_gene_id： 17125/17129/55994
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17125
Rat_gene_id： 59328/85435
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59328
Rat_swiss_prot_no： P97588/Q9R1V3/O54835
Rat_swiss_link： http://www.uniprot.org/uniprot/P97588
特异性： Smad1/5/9 Polyclonal Antibody detects endogenous levels of Smad1/5/9 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein
实测条带： 56kD
信号通路： TGF-beta;
功能： function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).,PTM:Phosphorylated on serine by BMP type 1 receptor kinase.,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.,tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.,
相关产品： YT6085,YT4325,KA4360C,KA3763C
细胞定位： Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). .
组织表达： Ubiquitous. Highest expression seen in the heart and skeletal muscle.
科研货号： PLA018145

Smad1/5/9 Polyclonal Antibody

Catalog No PLA018145

Product information

基因名称： SMAD1/SMAD5/SMAD9
蛋白名称： Mothers against decapentaplegic homolog 1/Mothers against decapentaplegic homolog 5/Mothers against decapentaplegic homolog 9
Human_gene_id： 4086/4090/4093
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4086
Human_swiss_prot_no： Q15797/Q99717/O15198
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15797/entry
Mouse_gene_id： 17125/17129/55994
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17125
Rat_gene_id： 59328/85435
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59328
Rat_swiss_prot_no： P97588/Q9R1V3/O54835
Rat_swiss_link： http://www.uniprot.org/uniprot/P97588
特异性： Smad1/5/9 Polyclonal Antibody detects endogenous levels of Smad1/5/9 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein
实测条带： 56kD
信号通路： TGF-beta;
功能： function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).,PTM:Phosphorylated on serine by BMP type 1 receptor kinase.,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.,tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.,
相关产品： YT6085,YT4325,KA4360C,KA3763C
细胞定位： Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). .
组织表达： Ubiquitous. Highest expression seen in the heart and skeletal muscle.
科研货号： PLA018145

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