Skp2 p45 Polyclonal Antibody

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商品货号： PLA018133

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： SKP2
蛋白名称： S-phase kinase-associated protein 2
Human_gene_id： 6502
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6502
Human_swiss_prot_no： Q13309
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13309/entry
Mouse_swiss_prot_no： Q9Z0Z3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z0Z3
特异性： Skp2 p45 Polyclonal Antibody detects endogenous levels of Skp2 p45 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SKP2; FBXL1; S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2
实测条带： 47kD
信号通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Ubiquitin mediated proteolysis;Pathways in cancer;Small cell lung cancer;
功能： function:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1L, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 F-box domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Part of the SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin A-CDK2 complex. Interacts with ORC1L, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1A, UBP43, MYC, TOB1, TAL1 and MLL.,
相关产品： YT4311,YM0579,KA3378C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus .
组织表达： Epithelium,Liver,Placenta,Prostatic carcinoma,
科研货号： PLA018133

Skp2 p45 Polyclonal Antibody

Catalog No PLA018133

Product information

基因名称： SKP2
蛋白名称： S-phase kinase-associated protein 2
Human_gene_id： 6502
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6502
Human_swiss_prot_no： Q13309
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13309/entry
Mouse_swiss_prot_no： Q9Z0Z3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z0Z3
特异性： Skp2 p45 Polyclonal Antibody detects endogenous levels of Skp2 p45 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SKP2; FBXL1; S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2
实测条带： 47kD
信号通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Ubiquitin mediated proteolysis;Pathways in cancer;Small cell lung cancer;
功能： function:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1L, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 F-box domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Part of the SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin A-CDK2 complex. Interacts with ORC1L, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1A, UBP43, MYC, TOB1, TAL1 and MLL.,
相关产品： YT4311,YM0579,KA3378C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus .
组织表达： Epithelium,Liver,Placenta,Prostatic carcinoma,
科研货号： PLA018133

Hunan UPT Biotechnology Co.,Ltd

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