SERCA1 Polyclonal Antibody

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商品货号： PLA018079

适应性： 人,小鼠,大鼠,火蜥蜴,猪

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： ATP2A1
蛋白名称： Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Human_gene_id： 487
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=487
Human_swiss_prot_no： O14983
Human_swiss_link： http://www.uniprot.org/uniprotkb/O14983/entry
Mouse_gene_id： 11937
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11937
Mouse_swiss_prot_no： Q8R429
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8R429
Rat_gene_id： 116601
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116601
Rat_swiss_prot_no： Q64578
Rat_swiss_link： http://www.uniprot.org/uniprot/Q64578
特异性： SERCA1 Polyclonal Antibody detects endogenous levels of SERCA1 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ATP2A1; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type; fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) AT
实测条带： 100kD
信号通路： Calcium;Alzheimer's disease;
功能： catalytic activity:ATP + H(2)O + Ca(2+)(Cis) = ADP + phosphate + Ca(2+)(Trans).,developmental stage:Isoform SERCA1A accounts for more than 99% of SERCA1 isoforms expressed in adult, while isoform SERCA1B predominates in neo-natal fibers.,disease:Defects in ATP2A1 are the cause of Brody disease (BD) [MIM:601003]. BD is an autosomal recessive myopathy characterized by increasing impairment of relaxation of fast twist skeletal muscle during exercise.,enzyme regulation:Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN.,function:This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.,induction:Increased contractile activity leads to decrease SERCA1 expression, while decreased contractile activity leads to increase of SERCA1 expression.,similarity:Belongs to the cation transport ATPase (P-type) family.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily.,subunit:Associated with sarcolipin (SLN) and phospholamban (PLN).,tissue specificity:Skeletal muscle, fast twitch muscle (type II) fibers.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达： Skeletal muscle, fast twitch muscle (type II) fibers.
科研货号： PLA018079

SERCA1 Polyclonal Antibody

Catalog No PLA018079

Product information

基因名称： ATP2A1
蛋白名称： Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Human_gene_id： 487
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=487
Human_swiss_prot_no： O14983
Human_swiss_link： http://www.uniprot.org/uniprotkb/O14983/entry
Mouse_gene_id： 11937
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11937
Mouse_swiss_prot_no： Q8R429
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8R429
Rat_gene_id： 116601
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116601
Rat_swiss_prot_no： Q64578
Rat_swiss_link： http://www.uniprot.org/uniprot/Q64578
特异性： SERCA1 Polyclonal Antibody detects endogenous levels of SERCA1 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ATP2A1; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type; fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) AT
实测条带： 100kD
信号通路： Calcium;Alzheimer's disease;
功能： catalytic activity:ATP + H(2)O + Ca(2+)(Cis) = ADP + phosphate + Ca(2+)(Trans).,developmental stage:Isoform SERCA1A accounts for more than 99% of SERCA1 isoforms expressed in adult, while isoform SERCA1B predominates in neo-natal fibers.,disease:Defects in ATP2A1 are the cause of Brody disease (BD) [MIM:601003]. BD is an autosomal recessive myopathy characterized by increasing impairment of relaxation of fast twist skeletal muscle during exercise.,enzyme regulation:Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN.,function:This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.,induction:Increased contractile activity leads to decrease SERCA1 expression, while decreased contractile activity leads to increase of SERCA1 expression.,similarity:Belongs to the cation transport ATPase (P-type) family.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily.,subunit:Associated with sarcolipin (SLN) and phospholamban (PLN).,tissue specificity:Skeletal muscle, fast twitch muscle (type II) fibers.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达： Skeletal muscle, fast twitch muscle (type II) fibers.
科研货号： PLA018079

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