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S2P Polyclonal Antibody
商品货号: PLA018032
适 应 性: 人,小鼠,大鼠
WB IF ELISA IP
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: MBTPS2
  • 蛋白名称: Membrane-bound transcription factor site-2 protease
  • Human_gene_id: 51360
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51360
  • Human_swiss_prot_no: O43462
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/O43462/entry
  • Mouse_gene_id: 270669
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=270669
  • Mouse_swiss_prot_no: Q8CHX6
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q8CHX6
  • 特异性: S2P Polyclonal Antibody detects endogenous levels of S2P protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000 IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MBTPS2; S2P; Membrane-bound transcription factor site-2 protease; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease
  • 分子量: 57kD
  • 功能: catalytic activity:Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.,cofactor:Binds 1 zinc ion per subunit.,function:Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.,similarity:Belongs to the peptidase M50A family.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Membrane ; Multi-pass membrane protein . Cytoplasm .
  • 组织表达: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
  • tag: hot
  • 科研货号: PLA018032
S2P Polyclonal Antibody
Catalog No PLA018032
Product information
  • 基因名称: MBTPS2
  • 蛋白名称: Membrane-bound transcription factor site-2 protease
  • Human_gene_id: 51360
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51360
  • Human_swiss_prot_no: O43462
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/O43462/entry
  • Mouse_gene_id: 270669
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=270669
  • Mouse_swiss_prot_no: Q8CHX6
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q8CHX6
  • 特异性: S2P Polyclonal Antibody detects endogenous levels of S2P protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000 IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MBTPS2; S2P; Membrane-bound transcription factor site-2 protease; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease
  • 分子量: 57kD
  • 功能: catalytic activity:Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.,cofactor:Binds 1 zinc ion per subunit.,function:Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.,similarity:Belongs to the peptidase M50A family.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Membrane ; Multi-pass membrane protein . Cytoplasm .
  • 组织表达: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
  • tag: hot
  • 科研货号: PLA018032
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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